Regulation of Gene Expression by Modulating MicroRNAs Through Epigallocatechin-3-gallate in Cancer

Overview

Journal Mol Biol Rep

Specialty Molecular Biology

Date 2024 Jan 28

PMID 38281210

Authors

Loganathan Chandramani Priya Dharshini

Abul Kalam Azad Mandal

Affiliations

Soon will be listed here.

Abstract

Cancer is an intricate ailment that has a higher death rate globally and is characterized by aberrant cell proliferation and metastasis in nature. Since the beginning of healthcare, natural products, especially those derived from plants, have been utilized to support human health. Green tea contains an essential catechin called epigallocatechin gallate, which has anti-proliferative, anti-mutagenic, anti-inflammatory, and antioxidative properties. The anticancer properties of EGCG have been extensively studied using pre-clinical cell culture and animal model systems. Dysregulated miRNA may be a biomarker since it influences the different characteristics of cancer like upholding proliferative signaling, cell death, invasiveness, metastasis, and angiogenesis. EGCG either elevates or lowers the expression of dysregulated miRNAs in cancer. Nonetheless, due to its anticancer properties, greater attention has been paid towards the development of efficient strategies for utilizing EGCG in cancer chemotherapy. This review summarizes the modifying effect of EGCG on miRNAs in cancer after briefly discussing the anticancer mechanisms of EGCG and the function of miRNAs in cancer.

Citing Articles

Epigallocatechin-3-gallate therapeutic potential in human diseases: molecular mechanisms and clinical studies.

Alam M, Gulzar M, Akhtar M, Rashid S, Zulfareen , Tanuja Mol Biomed. 2024; 5(1):73.

PMID: 39725830 PMC: 11671467. DOI: 10.1186/s43556-024-00240-9.

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