The Role of Intestinal Microbiota and Diet As Modulating Factors in the Course of Alzheimer's and Parkinson's Diseases

Overview

Journal Nutrients

Date 2024 Jan 26

PMID 38276546

Authors

Witold Czarnik

Piotr Fularski

Agata Gajewska

Paulina Jakubowska

Zofia Uszok

Ewelina Mlynarska

Jacek Rysz

Beata Franczyk

Affiliations

Soon will be listed here.

Abstract

Many researchers propose manipulating microbiota to prevent and treat related diseases. The brain-gut axis is an object that remains the target of modern research, and it is not without reason that many researchers enrich it with microbiota and diet in its name. Numerous connections and mutual correlations have become the basis for seeking answers to many questions related to pathology as well as human physiology. Disorders of this homeostasis as well as dysbiosis itself accompany neurodegenerative diseases such as Alzheimer's and Parkinson's. Heavily dependent on external factors, modulation of the gut microbiome represents an opportunity to advance the treatment of neurodegenerative diseases. Probiotic interventions, synbiotic interventions, or fecal transplantation can undoubtedly support the biotherapeutic process. A special role is played by diet, which provides metabolites that directly affect the body and the microbiota. A holistic view of the human organism is therefore essential.

Citing Articles

Acid-assisted polysaccharides extracted from protect against Alzheimer's disease by regulating the microbiota-gut-brain axis.

Li R, Wang H, Wang Q, Zhang Z, Wang L Front Nutr. 2025; 11:1496306.

PMID: 39758321 PMC: 11696728. DOI: 10.3389/fnut.2024.1496306.

Fecal microbiota transplantation for glaucoma; a potential emerging treatment strategy.

Ebrahimi R, Farsi Y, Nejadghaderi S Curr Res Microb Sci. 2024; 7:100314.

PMID: 39726974 PMC: 11670420. DOI: 10.1016/j.crmicr.2024.100314.

The gut-eye axis: from brain neurodegenerative diseases to age-related macular degeneration.

Jin Q, Wang S, Yao Y, Jiang Q, Li K Neural Regen Res. 2024; 20(10):2741-2757.

PMID: 39435619 PMC: 11826455. DOI: 10.4103/NRR.NRR-D-24-00531.

The Brain-Gut Axis, an Important Player in Alzheimer and Parkinson Disease: A Narrative Review.

Caradonna E, Nemni R, Bifone A, Gandolfo P, Costantino L, Giordano L J Clin Med. 2024; 13(14).

PMID: 39064171 PMC: 11278248. DOI: 10.3390/jcm13144130.

Exploring the Significance of Gut Microbiota in Diabetes Pathogenesis and Management-A Narrative Review.

Mlynarska E, Wasiak J, Gajewska A, Stec G, Jasinska J, Rysz J Nutrients. 2024; 16(12).

PMID: 38931292 PMC: 11206785. DOI: 10.3390/nu16121938.

References

Inagaki T, Moschetta A, Lee Y, Peng L, Zhao G, Downes M . Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proc Natl Acad Sci U S A. 2006; 103(10):3920-5. PMC: 1450165. DOI: 10.1073/pnas.0509592103. View

Alfonsetti M, Castelli V, dAngelo M . Are We What We Eat? Impact of Diet on the Gut-Brain Axis in Parkinson's Disease. Nutrients. 2022; 14(2). PMC: 8780419. DOI: 10.3390/nu14020380. View

Grochowska K, Przeliorz A . The Effect of the Ketogenic Diet on the Therapy of Neurodegenerative Diseases and Its Impact on Improving Cognitive Functions. Dement Geriatr Cogn Dis Extra. 2022; 12(2):100-106. PMC: 9247494. DOI: 10.1159/000524331. View

Rutayisire E, Huang K, Liu Y, Tao F . The mode of delivery affects the diversity and colonization pattern of the gut microbiota during the first year of infants' life: a systematic review. BMC Gastroenterol. 2016; 16(1):86. PMC: 4967522. DOI: 10.1186/s12876-016-0498-0. View

Vogt N, Kerby R, Dill-McFarland K, Harding S, Merluzzi A, Johnson S . Gut microbiome alterations in Alzheimer's disease. Sci Rep. 2017; 7(1):13537. PMC: 5648830. DOI: 10.1038/s41598-017-13601-y. View

Bailey M, Holscher H . Microbiome-Mediated Effects of the Mediterranean Diet on Inflammation. Adv Nutr. 2018; 9(3):193-206. PMC: 5952955. DOI: 10.1093/advances/nmy013. View

Swer N, Venkidesh B, Murali T, Mumbrekar K . Gut microbiota-derived metabolites and their importance in neurological disorders. Mol Biol Rep. 2022; 50(2):1663-1675. PMC: 9889412. DOI: 10.1007/s11033-022-08038-0. View

Majid N, Siddiqi M, Khan A, Shabnam S, Malik S, Alam A . Biophysical Elucidation of Amyloid Fibrillation Inhibition and Prevention of Secondary Nucleation by Cholic Acid: An Unexplored Function of Cholic Acid. ACS Chem Neurosci. 2019; 10(11):4704-4715. DOI: 10.1021/acschemneuro.9b00482. View

Fung T, Chiuve S, McCullough M, Rexrode K, Logroscino G, Hu F . Adherence to a DASH-style diet and risk of coronary heart disease and stroke in women. Arch Intern Med. 2008; 168(7):713-20. DOI: 10.1001/archinte.168.7.713. View

10.

Jandhyala S, Talukdar R, Subramanyam C, Vuyyuru H, Sasikala M, Reddy D . Role of the normal gut microbiota. World J Gastroenterol. 2015; 21(29):8787-803. PMC: 4528021. DOI: 10.3748/wjg.v21.i29.8787. View

11.

Zhu G, Zhao J, Zhang H, Wang G, Chen W . Gut Microbiota and its Metabolites: Bridge of Dietary Nutrients and Alzheimer's Disease. Adv Nutr. 2023; 14(4):819-839. PMC: 10334159. DOI: 10.1016/j.advnut.2023.04.005. View

12.

Mahmoudiandehkordi S, Arnold M, Nho K, Ahmad S, Jia W, Xie G . Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome. Alzheimers Dement. 2018; 15(1):76-92. PMC: 6487485. DOI: 10.1016/j.jalz.2018.07.217. View

13.

Dynka D, Kowalcze K, Paziewska A . The Role of Ketogenic Diet in the Treatment of Neurological Diseases. Nutrients. 2022; 14(23). PMC: 9739023. DOI: 10.3390/nu14235003. View

14.

Soria Lopez J, Gonzalez H, Leger G . Alzheimer's disease. Handb Clin Neurol. 2019; 167:231-255. DOI: 10.1016/B978-0-12-804766-8.00013-3. View

15.

Hirayama M, Ohno K . Parkinson's Disease and Gut Microbiota. Ann Nutr Metab. 2021; 77 Suppl 2:28-35. DOI: 10.1159/000518147. View

16.

Sun Y, Koyama Y, Shimada S . Inflammation From Peripheral Organs to the Brain: How Does Systemic Inflammation Cause Neuroinflammation?. Front Aging Neurosci. 2022; 14:903455. PMC: 9244793. DOI: 10.3389/fnagi.2022.903455. View

17.

Andreu-Reinon M, Chirlaque M, Gavrila D, Amiano P, Mar J, Tainta M . Mediterranean Diet and Risk of Dementia and Alzheimer's Disease in the EPIC-Spain Dementia Cohort Study. Nutrients. 2021; 13(2). PMC: 7927039. DOI: 10.3390/nu13020700. View

18.

Khan S, Barve K, Kumar M . Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer's Disease. Curr Neuropharmacol. 2020; 18(11):1106-1125. PMC: 7709159. DOI: 10.2174/1570159X18666200528142429. View

19.

Gubert C, Gasparotto J, Morais L . Convergent pathways of the gut microbiota-brain axis and neurodegenerative disorders. Gastroenterol Rep (Oxf). 2022; 10:goac017. PMC: 9109005. DOI: 10.1093/gastro/goac017. View

20.

Cabrera-Rivera G, Madera-Sandoval R, Leon-Pedroza J, Ferat-Osorio E, Salazar-Rios E, Hernandez-Aceves J . Increased TNF-α production in response to IL-6 in patients with systemic inflammation without infection. Clin Exp Immunol. 2022; 209(2):225-235. PMC: 9390847. DOI: 10.1093/cei/uxac055. View