Study on Osseointegration Capability of β-Type Ti-Nb-Zr-Ta-Si Alloy for Orthopedic Implants

Overview

Journal Materials (Basel)

Publisher MDPI

Date 2024 Jan 26

PMID 38276411

Authors

Yu Sun

Qingping Liu

Zhenglei Yu

Luquan Ren

Xin Zhao

Jincheng Wang

Affiliations

Soon will be listed here.

Abstract

Osseointegration is the basic condition for orthopedic implants to maintain long-term stability. In order to achieve osseointegration, a low elastic modulus is the most important performance indicator. It is difficult for traditional titanium alloys to meet this requirement. A novel β-titanium alloy (Ti-35Nb-7Zr-5Ta)Si was designed, which had excellent strength (a yield strength of 1296 MPa and a breaking strength 3263 MPa), an extremely low elastic modulus (37 GPa), and did not contain toxic elements. In previous in vitro studies, we confirmed the good biocompatibility of this alloy and similar bioactivity to Ti-6Al-4V, but no in vivo study was performed. In this study, Ti-6Al-4V and (Ti-35Nb-7Zr-5Ta)Si were implanted into rabbit femurs. Imaging evaluation and histological morphology were performed, and the bonding strength and bone contact ratio of the two alloys were measured and compared. The results showed that both alloys remained in their original positions 3 months after implantation, and neither imaging nor histological observations found inflammatory reactions in the surrounding bone. The bone-implant contact ratio and bonding strength of (Ti-35Nb-7Zr-5Ta)Si were significantly higher than those of Ti-6Al-4V. The results confirmed that (Ti-35Nb-7Zr-5Ta)Si has a better osseointegration ability than Ti-6Al-4V and is a promising material for orthopedic implants.

Citing Articles

Optimizing Suitable Mechanical Properties for a Biocompatible Beta-Titanium Alloy by Combining Plastic Deformation with Solution Treatment.

Irimescu R, Raducanu D, Nocivin A, Cojocaru E, Cojocaru V, Zarnescu-Ivan N Materials (Basel). 2024; 17(23).

PMID: 39685263 PMC: 11641965. DOI: 10.3390/ma17235828.

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