Torque Teno Virus (TTV)-A Potential Marker of Immunocompetence in Solid Organ Recipients

Overview

Journal Viruses

Publisher MDPI

Specialty Microbiology

Date 2024 Jan 26

PMID 38275952

Authors

Agnieszka Kuczaj

Piotr Przybylowski

Tomasz Hrapkowicz

Affiliations

Soon will be listed here.

Abstract

Torque Teno Virus (TTV), first discovered in 1997, is a non-pathogenic, highly prevalent virus with a notable presence in the human virome. TTV has garnered attention as a potential indicator of immunocompetence in recipients of solid organ transplants. In this review, we discuss the role of TTV as a potential marker for immunosuppression optimization, prediction of graft rejection, and as an indicator of opportunistic infections. We discuss TTV's behavior over the course of time after transplantation, TTV's implications in different immunosuppressive regimens, and potential utility in vaccinations. The review synthetizes findings from various studies depicting its potential clinical utility for future personalized patient care.

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