Late Local Recurrence After Neoadjuvant Therapy and Radical Resection for Locally Advanced Rectal Cancer

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2024 Jan 26

PMID 38275889

Authors

Adrian Salega

Marina Munch

Philipp Renner

Klaus-Peter Thon

Wolfgang Steurer

Dina Monch

Jana Koch

Annika Maass

Hans Jurgen Schlitt

Marc-Hendrik Dahlke

Tobias Leibold

Affiliations

Soon will be listed here.

Abstract

Neoadjuvant radiochemotherapy (RCT) and lately total neoadjuvant therapy (TNT) improved local recurrence rates of rectal cancer significantly compared to total mesorectal excision (TME) alone. Yet the occurrence and impact of late local recurrences after many years appears to be a distinct biological problem. We included = 188 patients with rectal cancer after RCT and radical resection in this study; = 38 of which had recurrent disease (sites: local (8.0%), liver (6.4%), lung (3.7%)). We found that 68% of all recurrences developed within the first two years. Four patients, however, experience recurrence >8 years after surgery. Here, we report and characterize four cases of late local recurrence (10% of patients with recurrent disease), suggesting that neoadjuvant therapy in principle delays local recurrence.

Citing Articles

Does Total Neoadjuvant Therapy Impact Surgical Precision in Total Mesorectal Excision? A Nationwide Survey of the Experiences of Expert Surgeons.

Jager T, Zitt M, Riss S, Presl J, Schredl P, Neureiter D Cancers (Basel). 2025; 17(2.

PMID: 39858065 PMC: 11763819. DOI: 10.3390/cancers17020283.

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