The Dynamic SUMOylation Changes and Their Potential Role in the Senescence of APOE4 Mice

Overview

Journal Biomedicines

Specialty Biomedical Engineering

Date 2024 Jan 26

PMID 38275378

Authors

Yangqi Xu

Wenwen Cai

Shaoming Sang

Xiaoqin Cheng

Boru Jin

Xiangteng Zhao

Chunjiu Zhong

Affiliations

Soon will be listed here.

Abstract

The ε4 allele of apolipoprotein E (APOE4) and aging are the major risk factors for Alzheimer's disease (AD). SUMOylation is intimately linked to the development of AD and the aging process. However, the SUMOylation status in APOE4 mice has not been uncovered. In this study, we investigated SENP1 and SUMOylation changes in the brains of aged APOE3 and APOE4 mice, aiming to understand their potential impact on mitochondrial metabolism and their contribution to cellular senescence in APOE4 mice. Concurrently, SUMO1-conjugated protein levels decreased, while SUMO2/3-conjugated protein levels increased relatively with the aging of APOE4 mice. This suggests that the equilibrium between the SUMOylation and deSUMOylation processes may be associated with senescence and longevity. Our findings highlight the significant roles of SENP1 and SUMOylation changes in APOE4-driven pathology and the aging process.

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