Oxidative Stress and the Pathogenesis of Aortic Aneurysms

Overview

Journal Biomedicines

Specialty Biomedical Engineering

Date 2024 Jan 26

PMID 38275364

Authors

Matthew Kazaleh

Rachel Gioscia-Ryan

Gorav Ailawadi

Morgan Salmon

Affiliations

Soon will be listed here.

Abstract

Aortic aneurysms are responsible for significant morbidity and mortality. Despite their clinical significance, there remain critical knowledge gaps in the pathogenesis of aneurysm disease and the mechanisms involved in aortic rupture. Recent studies have drawn attention to the role of reactive oxygen species (ROS) and their down-stream effectors in chronic cardiovascular diseases and specifically in the pathogenesis of aortic aneurysm formation. This review will discuss current mechanisms of ROS in mediating aortic aneurysms, the failure of endogenous antioxidant systems in chronic vascular diseases, and their relation to the development of aortic aneurysms.

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