The Potential Role of Hippo Pathway Regulates Cellular Metabolism Via Signaling Crosstalk in Disease-induced Macrophage Polarization

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2024 Jan 26

PMID 38274792

Authors

Yina An

Shuyu Tan

Jingjing Yang

Ting Gao

Yanjun Dong

Affiliations

Soon will be listed here.

Abstract

Macrophages polarized into distinct phenotypes play vital roles in inflammatory diseases by clearing pathogens, promoting tissue repair, and maintaining homeostasis. Metabolism serves as a fundamental driver in regulating macrophage polarization, and understanding the interplay between macrophage metabolism and polarization is crucial for unraveling the mechanisms underlying inflammatory diseases. The intricate network of cellular signaling pathway plays a pivotal role in modulating macrophage metabolism, and growing evidence indicates that the Hippo pathway emerges as a central player in network of cellular metabolism signaling. This review aims to explore the impact of macrophage metabolism on polarization and summarize the cell signaling pathways that regulate macrophage metabolism in diseases. Specifically, we highlight the pivotal role of the Hippo pathway as a key regulator of cellular metabolism and reveal its potential relationship with metabolism in macrophage polarization.

Citing Articles

Interplay of Glucose Metabolism and Hippo Pathway in Chondrocytes: Pathophysiology and Therapeutic Targets.

Jahn J, Ehlen Q, Kaplan L, Best T, Meng Z, Huang C Bioengineering (Basel). 2024; 11(10).

PMID: 39451348 PMC: 11505586. DOI: 10.3390/bioengineering11100972.

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