Key Enzymes Involved in the Utilization of Fatty Acids by : a Review

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2024 Jan 26

PMID 38274755

Authors

Zhaoyun Wang

Chunli Su

YiSang Zhang

SiFan ShangGuan

Ruiming Wang

Jing Su

Affiliations

Soon will be listed here.

Abstract

is a eukaryotic organism with a clear genetic background and mature gene operating system; in addition, it exhibits environmental tolerance. Therefore, is one of the most commonly used organisms for the synthesis of biological chemicals. The investigation of fatty acid catabolism in is crucial for the synthesis and accumulation of fatty acids and their derivatives, with β-oxidation being the predominant pathway responsible for fatty acid metabolism in this organism, occurring primarily within peroxisomes. The latest research has revealed distinct variations in β-oxidation among different fatty acids, primarily attributed to substrate preferences and disparities in the metabolic regulation of key enzymes involved in the fatty acid metabolic pathway. The synthesis of lipids, on the other hand, represents another crucial metabolic pathway for fatty acids. The present paper provides a comprehensive review of recent research on the key factors influencing the efficiency of fatty acid utilization, encompassing β-oxidation and lipid synthesis pathways. Additionally, we discuss various approaches for modifying β-oxidation to enhance the synthesis of fatty acids and their derivatives in , aiming to offer theoretical support and serve as a valuable reference for future studies.

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