Oxytocin Augmentation and Neurotransmitters in Prolonged Delivery: An Experimental Appraisal

Overview

Journal Eur J Obstet Gynecol Reprod Biol X

Specialty Gynecology & Obstetrics

Date 2024 Jan 26

PMID 38274243

Authors

Antonio Malvasi

Andrea Ballini

Andrea Tinelli

Bernard Fioretti

Antonella Vimercati

Elko Gliozheni

Giorgio Maria Baldini

Eliano Cascardi

Miriam Dellino

Monica Bonetti

Ettore Cicinelli

Amerigo Vitagliano

Gianluca Raffaello Damiani

Affiliations

Soon will be listed here.

Abstract

The uterus is a highly innervated organ, and during labor, this innervation is at its highest level. Oxytocinergic fibers play an important role in labor and delivery and, in particular, the Lower Uterine Segment, cervix, and fundus are all controlled by motor neurofibers. Oxytocin is a neurohormone that acts on receptors located on the membrane of the smooth cells of the myometrium. During the stages of labor and delivery, its binding causes myofibers to contract, which enables the fundus of the uterus to act as a mediator. The aim of this study was to investigate the presence of oxytocinergic fibers in prolonged and non-prolonged dystocic delivery in a cohort of 90 patients, evaluated during the first and second stages of labor. Myometrial tissue samples were collected and evaluated by electron microscopy, in order to quantify differences in neurofibers concentrations between the investigated and control cohorts of patients. The authors of this experiment showed that the concentration of oxytocinergic fibers differs between non-prolonged and prolonged dystocic delivery. In particular, in prolonged dystocic delivery, compared to non-prolonged dystocic delivery, there is a lower amount of oxytocin fiber. The increase in oxytocin appeared to be ineffective in patients who experienced prolonged dystocic delivery, since the dystocic labor ended as a result of the altered presence of oxytocinergic fibers detected in this group of patients.

Citing Articles

Dystocia, Delivery, and Artificial Intelligence in Labor Management: Perspectives and Future Directions.

Malvasi A, Malgieri L, Stark M, Tinelli A J Clin Med. 2024; 13(21).

PMID: 39518549 PMC: 11546974. DOI: 10.3390/jcm13216410.

AIDA (Artificial Intelligence Dystocia Algorithm) in Prolonged Dystocic Labor: Focus on Asynclitism Degree.

Malvasi A, Malgieri L, Cicinelli E, Vimercati A, Achiron R, Sparic R J Imaging. 2024; 10(8).

PMID: 39194983 PMC: 11355300. DOI: 10.3390/jimaging10080194.

Localization of Catecholaminergic Neurofibers in Pregnant Cervix as a Possible Myometrial Pacemaker.

Malvasi A, Baldini G, Cicinelli E, DI Naro E, Baldini D, Favilli A Int J Mol Sci. 2024; 25(11).

PMID: 38891818 PMC: 11171499. DOI: 10.3390/ijms25115630.

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