Reflex Human Immunodeficiency Virus (HIV) Type 1 RNA Testing Enables Timely Differentiation of False-Positive Results From Acute HIV Infection

Overview

Journal Open Forum Infect Dis

Specialty Infectious Diseases

Date 2024 Jan 25

PMID 38269050

Authors

Christopher Kaperak

Dylan Eller

Samantha A Devlin

Andre Hall

Jessica Schmitt

Eleanor E Friedman

Kathleen G Beavis

Kimberly A Stanford

David Pitrak

Moira C McNulty

Affiliations

Soon will be listed here.

Abstract

Accurate, timely human immunodeficiency virus (HIV) diagnosis is critical. Routine HIV screening program data were examined before and after reflex HIV type 1 RNA testing. Reflex testing facilitated confirmation of reactive HIV screening assays (as true or false positives) (odds ratio, 23.7 [95% confidence interval, 6.7-83.4]; < .0001), improving detection of acute HIV and reducing unconfirmed discordant results.

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