PI4KIIIβ-Mediated Phosphoinositides Metabolism Regulates Function of the VTA Dopaminergic Neurons and Depression-Like Behavior

Overview

Journal J Neurosci

Specialty Neurology

Date 2024 Jan 24

PMID 38267258

Authors

Yuqi Sang

Chenxu Niu

Jiaxi Xu

TianTian Zhu

Shuangzhu You

Jing Wang

Ludi Zhang

Xiaona Du

Hailin Zhang

Affiliations

Soon will be listed here.

Abstract

Phosphoinositides, including phosphatidylinositol-4,5-bisphosphate (PIP), play a crucial role in controlling key cellular functions such as membrane and vesicle trafficking, ion channel, and transporter activity. Phosphatidylinositol 4-kinases (PI4K) are essential enzymes in regulating the turnover of phosphoinositides. However, the functional role of PI4Ks and mediated phosphoinositide metabolism in the central nervous system has not been fully revealed. In this study, we demonstrated that PI4KIIIβ, one of the four members of PI4Ks, is an important regulator of VTA dopaminergic neuronal activity and related depression-like behavior of mice by controlling phosphoinositide turnover. Our findings provide new insights into possible mechanisms and potential drug targets for neuropsychiatric diseases, including depression. Both sexes were studied in basic behavior tests, but only male mice could be used in the social defeat depression model.

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