Nanoceria Anti-inflammatory and Antimicrobial Nanodrug: Cellular and Molecular Mechanism of Action

Overview

Journal Curr Med Chem

Publisher Bentham Science Publishers

Specialty Chemistry

Date 2024 Jan 24

PMID 38265391

Authors

Natalia Cristina Gomes-da-Silva

Luana Barbosa Correa

M MartInez Gonzalez

Mariana Martinez Gonzalez

Alefe Roger Silva Franca

Luciana Magalhaes Rebelo Alencar

Luciana M R Alencar

Elaine Cruz Rosas

Eduardo Ricci-Junior

Tawanny Kayonara Borges Aguiar

Pedro Filho Noronha Souza

Ralph Santos-Oliveira

Affiliations

Soon will be listed here.

Abstract

Introduction: Nanoceria is a well-known nanomaterial with various properties, including antioxidant, proangiogenic, and therapeutic effects. Despite its potential, there are still aspects that require further exploration, particularly its anti-inflammatory and antimicrobial activities.

Methods: The global demand for novel anti-inflammatory and antimicrobial drugs underscores the significance of understanding nanoceria in both contexts. In this study, we evaluated the effect of nanoceria on macrophage polarization to better understand its anti-inflammatory effects. Additionally, we investigated the mechanism of action of nanoceria against (ATCC 32045), (ATCC 22019), (ATCC 6258), and .

Results: The results demonstrated that nanoceria can polarize macrophages toward an anti-inflammatory profile, revealing the cellular mechanisms involved in the anti-inflammatory response. Concerning the antimicrobial effect, it was observed that nanoceria have a more pronounced impact on , leading to the formation of pronounced pores on the surface of this species.

Conclusion: Finally, biochemical analysis revealed transitory alterations, mainly in liver enzymes. The data support the use of nanoceria as a potential anti-inflammatory and antimicrobial drug and elucidate some of the mechanisms involved, shedding light on the properties of this nanodrug.

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