Possible Modulating Functions of Probiotic in Particulate Matter-associated Pulmonary Inflammation

Pulmonary disease represents a substantial global health burden. Increased air pollution, especially fine particulate matter (PM) is the most concerned proportion of air pollutants to respiratory health. PM may carry or combine with other toxic allergens and heavy metals, resulting in serious respiratory allergies and anaphylactic reactions in the host. Available treatment options such as antihistamines, steroids, and avoiding allergens/dust/pollutants could be limited due to certain side effects and immense exposure to air pollutants, especially in most polluted countries. In this mini-review, we summarized how PM triggers respiratory hyperresponsiveness and inflammation, and the probiotic supplementation could minimize the risk of the same. may confer beneficial effects in PM-associated pulmonary inflammation due to significant antioxidant potential. We discussed effect on PM-induced reactive oxygen species (ROS), inflammatory cytokines, lipid peroxidation, and DNA damage. Available preclinical evidence shows induces gut-lung axis, SCFA, GABA, and other neurotransmitter signaling via gut microbiota modulation. SCFA signals are important in maintaining lung homeostasis and regulating intracellular defense mechanisms in alveolar cells. However, significant research is needed in this direction to contemplate 's therapeutic potential in pulmonary allergies.