Infections After Liver Transplant -Timeline, Management and Prevention

Overview

Journal J Clin Exp Hepatol

Publisher Elsevier

Specialty Gastroenterology

Date 2024 Jan 24

PMID 38264574

Authors

Ajay S Shinde

Dharmesh Kapoor

Affiliations

Soon will be listed here.

Abstract

Liver transplantation (LT) is the standard treatment for end- stage liver disease. Patient and graft survival have improved significantly in the last three decades owing to improvement in surgical technique, better perioperative management and better immunosuppressive regimens. However, LT recipients are at increased risk of infections, particularly in the first year after transplantation. The risk of infection is directly proportional to immunosuppressive regimen and graft function. In this review, we will briefly discuss the timeline of infections after liver transplant, preventive strategies and management of infectious complications.

References

Singh N, Wagener M, Obman A, Cacciarelli T, de Vera M, Gayowski T . Bacteremias in liver transplant recipients: shift toward gram-negative bacteria as predominant pathogens. Liver Transpl. 2004; 10(7):844-9. DOI: 10.1002/lt.20214. View

Verolet C, Posfay-Barbe K . Live virus vaccines in transplantation: friend or foe?. Curr Infect Dis Rep. 2015; 17(4):472. DOI: 10.1007/s11908-015-0472-y. View

Russell D, Flood A, Zaroda T, Acosta C, Riley M, Busuttil R . Outcomes of colonization with MRSA and VRE among liver transplant candidates and recipients. Am J Transplant. 2008; 8(8):1737-43. DOI: 10.1111/j.1600-6143.2008.02304.x. View

Ha Y, Joo E, Park S, Wi Y, Kang C, Chung D . Tacrolimus as a risk factor for tuberculosis and outcome of treatment with rifampicin in solid organ transplant recipients. Transpl Infect Dis. 2012; 14(6):626-34. DOI: 10.1111/j.1399-3062.2012.00721.x. View

Eshraghian A, Imanieh M, Dehghani S, Nikeghbalian S, Shamsaeefar A, Barshans F . Post-transplant lymphoproliferative disorder after liver transplantation: Incidence, long-term survival and impact of serum tacrolimus level. World J Gastroenterol. 2017; 23(7):1224-1232. PMC: 5323447. DOI: 10.3748/wjg.v23.i7.1224. View

Torre-Cisneros J, Doblas A, Aguado J, San Juan R, Blanes M, Montejo M . Tuberculosis after solid-organ transplant: incidence, risk factors, and clinical characteristics in the RESITRA (Spanish Network of Infection in Transplantation) cohort. Clin Infect Dis. 2009; 48(12):1657-65. DOI: 10.1086/599035. View

Fishman J . Infection in solid-organ transplant recipients. N Engl J Med. 2007; 357(25):2601-14. DOI: 10.1056/NEJMra064928. View

Gupta S, Sudhindran S, Saraf N, Vijai A, Swaminathan S, Panackel C . Liver Transplant Society of India Guidelines for Liver Transplant During COVID-19 times. J Clin Exp Hepatol. 2021; 12(1):180-185. PMC: 8378015. DOI: 10.1016/j.jceh.2021.08.012. View

Verna E, Pereira M . Transplanting patients with active bacterial infection. Clin Liver Dis (Hoboken). 2019; 9(4):81-85. PMC: 6467147. DOI: 10.1002/cld.624. View

10.

Evans J, Morris P, Knight S . Antifungal prophylaxis in liver transplantation: a systematic review and network meta-analysis. Am J Transplant. 2014; 14(12):2765-76. DOI: 10.1111/ajt.12925. View

11.

Alukal J, Naqvi H, Thuluvath P . Vaccination in Chronic Liver Disease: An Update. J Clin Exp Hepatol. 2022; 12(3):937-947. PMC: 8710401. DOI: 10.1016/j.jceh.2021.12.003. View

12.

Barchiesi F, Mazzocato S, Mazzanti S, Gesuita R, Skrami E, Fiorentini A . Invasive aspergillosis in liver transplant recipients: epidemiology, clinical characteristics, treatment, and outcomes in 116 cases. Liver Transpl. 2014; 21(2):204-12. DOI: 10.1002/lt.24032. View

13.

Hernandez M, Martin P, Simkins J . Infectious Complications After Liver Transplantation. Gastroenterol Hepatol (N Y). 2016; 11(11):741-53. PMC: 4849501. View

14.

Yi S, Rogers A, Saharia A, Aoun M, Faour R, Abdelrahim M . Early Experience With COVID-19 and Solid Organ Transplantation at a US High-volume Transplant Center. Transplantation. 2020; 104(11):2208-2214. PMC: 7302089. DOI: 10.1097/TP.0000000000003339. View

15.

Doucette K, Al-Saif M, Kneteman N, Chui L, Tyrrell G, Kumar D . Donor-derived bacteremia in liver transplant recipients despite antibiotic prophylaxis. Am J Transplant. 2013; 13(4):1080-1083. DOI: 10.1111/ajt.12133. View

16.

Rubin R . The pathogenesis and clinical management of cytomegalovirus infection in the organ transplant recipient: the end of the 'silo hypothesis'. Curr Opin Infect Dis. 2007; 20(4):399-407. DOI: 10.1097/QCO.0b013e328285a358. View

17.

Levitsky J, Kalil A, Meza J, Hurst G, Freifeld A . Chicken pox after pediatric liver transplantation. Liver Transpl. 2005; 11(12):1563-6. DOI: 10.1002/lt.20527. View

18.

Bruminhent J, Razonable R . Management of cytomegalovirus infection and disease in liver transplant recipients. World J Hepatol. 2014; 6(6):370-83. PMC: 4081612. DOI: 10.4254/wjh.v6.i6.370. View

19.

Simor A, Porter V, Mubareka S, Chouinard M, Katz K, Vermeiren C . Rapid Identification of Candida Species from Positive Blood Cultures by Use of the FilmArray Blood Culture Identification Panel. J Clin Microbiol. 2018; 56(12). PMC: 6258842. DOI: 10.1128/JCM.01387-18. View

20.

Albright J, Bonatti H, Mendez J, Kramer D, Stauffer J, Hinder R . Early and late onset Clostridium difficile-associated colitis following liver transplantation. Transpl Int. 2007; 20(10):856-66. DOI: 10.1111/j.1432-2277.2007.00530.x. View