Using Intravoxel Incoherent Motion Imaging to Evaluate Uric Acid-induced Renal Injury and Efficacy After Treatment

Overview

Journal Br J Radiol

Publisher Oxford University Press

Specialty Radiology

Date 2024 Jan 24

PMID 38263841

Authors

Zhong-Yuan Cheng

Shang-Ao Gong

Ping-Kang Chen

Zong-Chao Yu

Chen Qiu

Ji-Xin Lin

Jia-Bin Mo

Long Qian

You-Zhen Feng

Xiang-Ran Cai

Affiliations

Soon will be listed here.

Abstract

Objectives: To validate the feasibility of intravoxel incoherent motion imaging (IVIM) for monitoring renal injury and uric acid-lowering efficacy in a rat model of hyperuricaemia.

Methods: A total of 92 rats were analysed and categorized into 4 groups: control (CON), hyperuricaemia (HUA), allopurinol intervention (ALL), and combined intervention (COM). Eight rats were randomly selected from each group and underwent IVIM scanning on days 0, 1, 3, 5, 7, and 9. Quantitative magnetic resonance values (D, D*, and f values) measured from the different renal anatomical regions. Quantitative histopathological analysis was performed to assess renal tubular injury using neutrophil gelatinase-associated lipocalin (NGAL), and renal fibrosis using alpha-smooth-muscle-actin (α-SMA). Pearson's correlation analysis was used to determine the correlation between IVIM-derived parameters and the expression of NGAL and α-SMA.

Results: The D values of the HUA, ALL, and COM groups generally showed a downward trend over time, and this fluctuation was most significant in the HUA group. The D values showed significant intergroup differences at each point, whereas only a few discrepancies were found in the D* and f values. In addition, the renal D value was negatively correlated with the positive staining rates for NGAL and α-SMA (P < .05), except for the lack of correlation between Dos and α-SMA (P > .05).

Conclusion: IVIM could be a noninvasive and potential assessment modality for the evaluation of renal injury induced by hyperuricaemia and its prognostic efficacy.

Advances In Knowledge: IVIM could be a surrogate manner in monitoring renal damage induced by hyperuricaemia and its treatment evaluation.

Citing Articles

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