Impact of Respiratory Viral Infections During Pregnancy on the Neurological Outcomes of the Newborn: Current Knowledge

Overview

Journal Front Neurosci

Date 2024 Jan 23

PMID 38260010

Authors

Sara Manti

Giulia Spoto

Antonio Gennaro Nicotera

Gabriella Di Rosa

Giovanni Piedimonte

Affiliations

Soon will be listed here.

Abstract

Brain development is a complex process that begins during pregnancy, and the events occurring during this sensitive period can affect the offspring's neurodevelopmental outcomes. Respiratory viral infections are frequently reported in pregnant women, and, in the last few decades, they have been related to numerous neuropsychiatric sequelae. Respiratory viruses can disrupt brain development by directly invading the fetal circulation through vertical transmission or inducing neuroinflammation through the maternal immune activation and production of inflammatory cytokines. Influenza virus gestational infection has been consistently associated with psychotic disorders, such as schizophrenia and autism spectrum disorder, while the recent pandemic raised some concerns regarding the effects of severe acute respiratory syndrome coronavirus 2 on neurodevelopmental outcomes of children born to affected mothers. In addition, emerging evidence supports the possible role of respiratory syncytial virus infection as a risk factor for adverse neuropsychiatric consequences. Understanding the mechanisms underlying developmental dysfunction allows for improving preventive strategies, early diagnosis, and prompt interventions.

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References

Lewis R, Baskaran H, Green J, Tashev S, Palaiologou E, Lofthouse E . 3D visualization of trans-syncytial nanopores provides a pathway for paracellular diffusion across the human placental syncytiotrophoblast. iScience. 2022; 25(12):105453. PMC: 9663330. DOI: 10.1016/j.isci.2022.105453. View

Knuesel I, Chicha L, Britschgi M, Schobel S, Bodmer M, Hellings J . Maternal immune activation and abnormal brain development across CNS disorders. Nat Rev Neurol. 2014; 10(11):643-60. DOI: 10.1038/nrneurol.2014.187. View

Li M, Chen L, Zhang J, Xiong C, Li X . The SARS-CoV-2 receptor ACE2 expression of maternal-fetal interface and fetal organs by single-cell transcriptome study. PLoS One. 2020; 15(4):e0230295. PMC: 7161957. DOI: 10.1371/journal.pone.0230295. View

Edlow A, Castro V, Shook L, Kaimal A, Perlis R . Neurodevelopmental Outcomes at 1 Year in Infants of Mothers Who Tested Positive for SARS-CoV-2 During Pregnancy. JAMA Netw Open. 2022; 5(6):e2215787. PMC: 9185175. DOI: 10.1001/jamanetworkopen.2022.15787. View

Hause A, Avadhanula V, Maccato M, Pinell P, Bond N, Santarcangelo P . Clinical characteristics and outcomes of respiratory syncytial virus infection in pregnant women. Vaccine. 2019; 37(26):3464-3471. PMC: 7126758. DOI: 10.1016/j.vaccine.2019.04.098. View

Limosin F, Rouillon F, Payan C, Cohen J, Strub N . Prenatal exposure to influenza as a risk factor for adult schizophrenia. Acta Psychiatr Scand. 2003; 107(5):331-5. DOI: 10.1034/j.1600-0447.2003.00052.x. View

Harry G, Lawler C, Brunssen S . Maternal infection and white matter toxicity. Neurotoxicology. 2006; 27(5):658-70. PMC: 1592133. DOI: 10.1016/j.neuro.2006.05.004. View

Taylor D, Pirianov G, Holland S, McGinnity C, Norman A, Reali C . Attenuation of proliferation in oligodendrocyte precursor cells by activated microglia. J Neurosci Res. 2010; 88(8):1632-44. DOI: 10.1002/jnr.22335. View

Gibney S, McGuinness B, Prendergast C, Harkin A, Connor T . Poly I:C-induced activation of the immune response is accompanied by depression and anxiety-like behaviours, kynurenine pathway activation and reduced BDNF expression. Brain Behav Immun. 2012; 28:170-81. DOI: 10.1016/j.bbi.2012.11.010. View

10.

Gordon-Lipkin E, Hoon A, Pardo C . Prenatal cytomegalovirus, rubella, and Zika virus infections associated with developmental disabilities: past, present, and future. Dev Med Child Neurol. 2020; 63(2):135-143. PMC: 7785600. DOI: 10.1111/dmcn.14682. View

11.

Kowash H, Potter H, Woods R, Ashton N, Hager R, Neill J . Maternal immune activation in rats induces dysfunction of placental leucine transport and alters fetal brain growth. Clin Sci (Lond). 2022; 136(15):1117-1137. PMC: 9366863. DOI: 10.1042/CS20220245. View

12.

CHESS S . Autism in children with congenital rubella. J Autism Child Schizophr. 1971; 1(1):33-47. DOI: 10.1007/BF01537741. View

13.

Short S, Lubach G, Karasin A, Olsen C, Styner M, Knickmeyer R . Maternal influenza infection during pregnancy impacts postnatal brain development in the rhesus monkey. Biol Psychiatry. 2010; 67(10):965-73. PMC: 3235476. DOI: 10.1016/j.biopsych.2009.11.026. View

14.

Kawashima H, Ioi H, Ushio M, Yamanaka G, Matsumoto S, Nakayama T . Cerebrospinal fluid analysis in children with seizures from respiratory syncytial virus infection. Scand J Infect Dis. 2009; 41(3):228-31. DOI: 10.1080/00365540802669543. View

15.

Kunugi H, Nanko S, Takei N, Saito K, Hayashi N, KAZAMATSURI H . Schizophrenia following in utero exposure to the 1957 influenza epidemics in Japan. Am J Psychiatry. 1995; 152(3):450-2. DOI: 10.1176/ajp.152.3.450. View

16.

Piedimonte G, Walton C, Samsell L . Vertical transmission of respiratory syncytial virus modulates pre- and postnatal innervation and reactivity of rat airways. PLoS One. 2013; 8(4):e61309. PMC: 3630224. DOI: 10.1371/journal.pone.0061309. View

17.

Nam H, Ison M . Respiratory syncytial virus infection in adults. BMJ. 2019; 366:l5021. DOI: 10.1136/bmj.l5021. View

18.

Manti S, Xerra F, Spoto G, Butera A, Gitto E, Di Rosa G . Neurotrophins: Expression of Brain-Lung Axis Development. Int J Mol Sci. 2023; 24(8). PMC: 10138985. DOI: 10.3390/ijms24087089. View

19.

Tiwari S, Wang S, Smith D, Carlin A, Rana T . Revealing Tissue-Specific SARS-CoV-2 Infection and Host Responses using Human Stem Cell-Derived Lung and Cerebral Organoids. Stem Cell Reports. 2021; 16(3):437-445. PMC: 7879814. DOI: 10.1016/j.stemcr.2021.02.005. View

20.

Andrade C, Kalergis A, Bohmwald K . Potential Neurocognitive Symptoms Due to Respiratory Syncytial Virus Infection. Pathogens. 2022; 11(1). PMC: 8780657. DOI: 10.3390/pathogens11010047. View