Pediatric Ewing Sarcoma of Kidney: A Case Series and Review of Literature

Overview

Journal J Cancer Allied Spec

Specialty Oncology

Date 2024 Jan 23

PMID 38259675

Authors

Areej Salim

Sajid Ali

Tariq Latif

Affiliations

Soon will be listed here.

Abstract

Introduction: Renal Ewing sarcoma is an aggressive and rare malignancy affecting children and adolescents. Limited data on its management contribute to uncertainties in treatment.

Case Description: We present two pediatric cases of renal Ewing sarcoma. Both cases emphasize the significance of accurate diagnosis, multimodal treatment, and long-term follow-up in achieving favorable outcomes. Accurate diagnosis of renal Ewing sarcoma is crucial for effective management. Multimodal treatment involving neoadjuvant chemotherapy, surgical resection and staging with lymph node sampling, and chemotherapy continuation has shown promising results in our cases. Long-term follow-up is essential for monitoring disease progression and ensuring optimal outcomes.

Practical Implications: There is limited data published about these renal tumors, especially in the pediatric population, and most studies lack long-term follow-up, with uncertain management due to limited data. This data will add to the newer, multimodal approach and form the basis for future meta-analysis to help formulate guidelines for upcoming international meetings. Continued research efforts are necessary to optimize strategies and improve the prognosis for pediatric patients with renal Ewing sarcoma.

References

Kushner B, HAJDU S, Gulati S, Erlandson R, Exelby P, Lieberman P . Extracranial primitive neuroectodermal tumors. The Memorial Sloan-Kettering Cancer Center experience. Cancer. 1991; 67(7):1825-9. DOI: 10.1002/1097-0142(19910401)67:7<1825::aid-cncr2820670702>3.0.co;2-3. View

Citak E, Oguz A, Karadeniz C, Okur A, Akyurek N . Primitive neuroectodermal tumor of the kidney in a child. Pediatr Hematol Oncol. 2009; 26(7):481-6. DOI: 10.1080/08880010902754792. View

Dirksen U, Brennan B, Le Deley M, Cozic N, van den Berg H, Bhadri V . High-Dose Chemotherapy Compared With Standard Chemotherapy and Lung Radiation in Ewing Sarcoma With Pulmonary Metastases: Results of the European Ewing Tumour Working Initiative of National Groups, 99 Trial and EWING 2008. J Clin Oncol. 2019; 37(34):3192-3202. PMC: 6881099. DOI: 10.1200/JCO.19.00915. View

Rodriguez-Galindo C, Marina N, Fletcher B, Parham D, Bodner S, Meyer W . Is primitive neuroectodermal tumor of the kidney a distinct entity?. Cancer. 1997; 79(11):2243-50. View

Seemayer T, Thelmo W, BOLANDE R, WIGLESWORTH F . Peripheral neuroectodermal tumors. Perspect Pediatr Pathol. 1975; 2:151-72. View

Faizan M, Anwar S, Iqbal S, Mehmood Q, Zaman S, Abbas N . Primary renal Ewing's sarcoma: a rare entity. J Coll Physicians Surg Pak. 2014; 24 Suppl 1:S66-7. DOI: 03.2014/JCPSP.S66S67. View

Das D, Datta C, Chatterjee U, Pal D . Primary Ewing sarcoma of the kidney in an adult and a child: Solving a diagnostic challenge. Indian J Pathol Microbiol. 2020; 63(Supplement):S61-S63. DOI: 10.4103/IJPM.IJPM_699_18. View

Womer R, West D, Krailo M, Dickman P, Pawel B, Grier H . Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children's Oncology Group. J Clin Oncol. 2012; 30(33):4148-54. PMC: 3494838. DOI: 10.1200/JCO.2011.41.5703. View

Almeida M, Patnana M, Rao Korivi B, Kalhor N, Marcal L . Ewing sarcoma of the kidney: a rare entity. Case Rep Radiol. 2014; 2014:283902. PMC: 3913202. DOI: 10.1155/2014/283902. View

10.

Benesch M, Urban C . Is primitive neuroectodermal tumor of the kidney a distinct entity?. Cancer. 1998; 82(7):1414-6. DOI: 10.1002/(sici)1097-0142(19980401)82:7<1414::aid-cncr34>3.0.co;2-7. View

11.

Murugan P, Rao P, Tamboli P, Czerniak B, Guo C . Primary Ewing Sarcoma / Primitive Neuroectodermal Tumor of the Kidney: A Clinicopathologic Study of 23 Cases. Pathol Oncol Res. 2017; 24(1):153-159. DOI: 10.1007/s12253-017-0228-0. View

12.

Aghili M, Rafiei E, Mojahed M, Zare M . Renal primitive neuroectodermal tumor: does age at diagnosis impact outcomes?. Rare Tumors. 2012; 4(1):e15. PMC: 3325742. DOI: 10.4081/rt.2012.e15. View

13.

Bradford K, Nobori A, Johnson B, Allen-Rhoades W, Naik-Mathuria B, Panosyan E . Primary Renal Ewing Sarcoma in Children and Young Adults. J Pediatr Hematol Oncol. 2020; 42(8):474-481. PMC: 7554078. DOI: 10.1097/MPH.0000000000001804. View

14.

Ladenstein R, Potschger U, Cecile Le Deley M, Whelan J, Paulussen M, Oberlin O . Primary disseminated multifocal Ewing sarcoma: results of the Euro-EWING 99 trial. J Clin Oncol. 2010; 28(20):3284-91. DOI: 10.1200/JCO.2009.22.9864. View

15.

Cotterill S, Ahrens S, Paulussen M, Jurgens H, VOUTE P, Gadner H . Prognostic factors in Ewing's tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing's Sarcoma Study Group. J Clin Oncol. 2000; 18(17):3108-14. DOI: 10.1200/JCO.2000.18.17.3108. View

16.

Applebaum M, Goldsby R, Neuhaus J, Dubois S . Clinical features and outcomes in patients with Ewing sarcoma and regional lymph node involvement. Pediatr Blood Cancer. 2011; 59(4):617-20. PMC: 3310932. DOI: 10.1002/pbc.24053. View

17.

Grier H, Krailo M, Tarbell N, Link M, Fryer C, Pritchard D . Addition of ifosfamide and etoposide to standard chemotherapy for Ewing's sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med. 2003; 348(8):694-701. DOI: 10.1056/NEJMoa020890. View

18.

Badar Q, Ali N, Abbasi N, Ashraf S, Karsan F, Hashmi R . Ewing's sarcoma/PNET of kidney in 13-year-old girl. J Pak Med Assoc. 2010; 60(4):314-5. View

19.

Folpe A, Hill C, Parham D, OShea P, Weiss S . Immunohistochemical detection of FLI-1 protein expression: a study of 132 round cell tumors with emphasis on CD99-positive mimics of Ewing's sarcoma/primitive neuroectodermal tumor. Am J Surg Pathol. 2000; 24(12):1657-62. DOI: 10.1097/00000478-200012000-00010. View

20.

Zollner S, Dirksen U, Jurgens H, Ranft A . Renal Ewing tumors. Ann Oncol. 2013; 24(9):2455-61. DOI: 10.1093/annonc/mdt215. View