Lung Fibroblasts Take Up Breast Cancer Cell-derived Extracellular Vesicles Partially Through MEK2-dependent Macropinocytosis

Overview

Journal Cancer Res Commun

Specialty Oncology

Date 2024 Jan 23

PMID 38259097

Authors

Yuhao Wan

Yue Zhao

Minghui Cao

Jingyi Wang

Sheila V Tran

Zhixuan Song

Brent W Hsueh

Shizhen Emily Wang

Affiliations

Soon will be listed here.

Abstract

Significance: Through a phenotypic screen, we found that MEK inhibitor Trametinib suppressed EV uptake and macropinocytosis in lung fibroblasts, and that EV uptake is mediated by MEK2 in these cells. Our results suggest that MEK2 inhibition could serve as a strategy to block cancer EV uptake by lung fibroblasts.

Citing Articles

Triple-Negative Breast Cancer EVs Modulate Growth and Migration of Normal Epithelial Lung Cells.

Leone I, Santoro J, Soricelli A, Febbraro A, Santoriello A, Carrese B Int J Mol Sci. 2024; 25(11).

PMID: 38892050 PMC: 11172765. DOI: 10.3390/ijms25115864.

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