An Overview of Different Vitamin D Compounds in the Setting of Adiposity
Overview
Affiliations
A large body of research shows an association between higher body weight and low vitamin D status, as assessed using serum 25-hydroxyvitamin D concentrations. Vitamin D can be metabolised in adipose tissue and has been reported to influence gene expression and modulate inflammation and adipose tissue metabolism in vitro. However, the exact metabolism of vitamin D in adipose tissue is currently unknown. White adipose tissue expresses the vitamin D receptor and hydroxylase enzymes, substantially involved in vitamin D metabolism and efficacy. The distribution and concentrations of the generated vitamin D compounds in adipose tissue, however, are largely unknown. Closing this knowledge gap could help to understand whether the different vitamin D compounds have specific health effects in the setting of adiposity. This review summarises the current evidence for a role of vitamin D in adipose tissue and discusses options to accurately measure vitamin D compounds in adipose tissue using liquid chromatography tandem mass spectrometry (LC/MS-MS).
Vitamin D Supplementation: Practical Advice in Different Clinical Settings.
Bendotti G, Biamonte E, Leporati P, Goglia U, Ruggeri R, Gallo M Nutrients. 2025; 17(5).
PMID: 40077652 PMC: 11901608. DOI: 10.3390/nu17050783.
Dominguez L, Veronese N, Marrone E, Di Palermo C, Iommi C, Ruggirello R Nutrients. 2024; 16(11).
PMID: 38892495 PMC: 11173817. DOI: 10.3390/nu16111561.
Stress and eating behaviors in young subjects can influence early cardiovascular prevention.
Mattioli A Cad Saude Publica. 2024; 40(3):e00017424.
PMID: 38477723 PMC: 10929879. DOI: 10.1590/0102-311XEN017424.