A Preliminary Study on Hepatoprotective, Hypolipidemic and Aortic Morphometric Effects of Omega-3-Rich Fish Oil in Hypercholesterolemic Mice

Overview

Journal Pharmaceuticals (Basel)

Publisher MDPI

Specialty Chemistry

Date 2024 Jan 23

PMID 38256905

Authors

Ana Lina C C Sales

Maisa G S Primo

Renato S Mello Neto

Ana Victoria S Mendes

Mariely M Furtado

Joana Erica L Rocha

Jose Otavio C S Almeida

Jose Vinicius S Franca

Salmon R Alencar

Ana Karolinne S Brito

Luana O Lopes

Marcia S Rizzo

Ana Karina M F Lustosa

Paulo Humberto M Nunes

Massimo Lucarini

Alessandra Durazzo

Daniel Dias Rufino Arcanjo

Maria do Carmo C Martins

Affiliations

Soon will be listed here.

Abstract

This study aims to evaluate the hepatoprotective, hypolipidemic and aortic morphometric effects of fish oil rich in omega-3 in hypercholesterolemic BALB/c mice. This is an experimental model that included 16 male BALB/c mice () divided into three groups (G1 (standard commercial chow and 0.9% saline solution), G2 (hypercholesterolemic diet and 0.9% saline solution) and G3 (hypercholesterolemic diet and fish oil)) for 8 weeks. There was no significant difference in the treatment with omega-3-rich fish oil in the lipid profile ( > 0.05). In the histological analysis, group G2 detected the presence of hepatitis and liver tissue necrosis, but this was not observed in group G3. As for the morphometry in the light area of the vessel, the G1 group had a higher score (2.62 ± 0.36 mm) when compared to G2 (2.10 ± 0.16 mm) and G3 (2.26 ± 0.25 mm) ( < 0.05). The vessel wall thickness did not differ between the groups ( > 0.05). It is concluded that supplementation with fish oil rich in omega-3 carried out in this study may have a protective effect on liver tissue, but it has not yet improved the lipid and morphometric profile. Despite this research being preliminary, it is a relevant study with future prospects for improving the doses of EPA and DHA in order to better elucidate the benefits of fish oil in models of dyslipidemia.

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