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Take My Breath Away-mitochondrial Dysfunction Drives CD8 T Cell Exhaustion

Overview
Journal Genes Immun
Date 2024 Jan 22
PMID 38253749
Authors
Felix Clemens Richter
Mariia Saliutina
Ahmed N Hegazy
Andreas Bergthaler
Affiliations
Soon will be listed here.
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References
1.
Zehn D, Thimme R, Lugli E, de Almeida G, Oxenius A . 'Stem-like' precursors are the fount to sustain persistent CD8 T cell responses. Nat Immunol. 2022; 23(6):836-847. DOI: 10.1038/s41590-022-01219-w. View
2.
Im S, Hashimoto M, Gerner M, Lee J, Kissick H, Burger M . Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy. Nature. 2016; 537(7620):417-421. PMC: 5297183. DOI: 10.1038/nature19330. View
3.
Chapman N, Chi H . Metabolic adaptation of lymphocytes in immunity and disease. Immunity. 2022; 55(1):14-30. PMC: 8842882. DOI: 10.1016/j.immuni.2021.12.012. View
4.
Bengsch B, Johnson A, Kurachi M, Odorizzi P, Pauken K, Attanasio J . Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8(+) T Cell Exhaustion. Immunity. 2016; 45(2):358-73. PMC: 4988919. DOI: 10.1016/j.immuni.2016.07.008. View
5.
Vardhana S, Hwee M, Berisa M, Wells D, Yost K, King B . Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen. Nat Immunol. 2020; 21(9):1022-1033. PMC: 7442749. DOI: 10.1038/s41590-020-0725-2. View