Genetic, Clinical, and Pathologic Backgrounds of Children With X-Linked Alport Syndrome in China: A Monocenter Study

Overview

Journal Glob Pediatr Health

Specialty Pediatrics

Date 2024 Jan 22

PMID 38249544

Authors

Ding Juan-Juan

Wang Jia

Liu Li-Li

Wang Si

Wang Xiao-Wen

Luan Jiang-Wei

Ke Li-Qin

Sun Jie

Zhao Pei-Wei

Affiliations

Soon will be listed here.

Abstract

. Characteristics of X-linked Alport syndrome (XLAS) in a cohort of Chinese children. . This work is a retrospective study covering the clinical information, pathological data, and gene sequencing results of 32 cases with XLAS from 2011 to 2022. . Among these 32 patients, the youngest age of onset was 3 months. Renal biopsy was performed on 29 children. The lamellated glomerular basement membrane was observed in 19 children using electron microscopy (65.5%). Of the 26 samples tested, 73.1% were found to be negative for collagen-a5 under immunohistochemical staining, showing clinical significance. Next-generation sequencing (NGS) detected 27 pathogenic gene mutations. A total of 15.4% of patients carried de novo mutations. . The boys with XLAS showed more typical pathological performance than the girls. Patients with severe mutation were more likely to have proteinuria and hearing impairment. Renal pathology combined with NSG is an important means of diagnosis of AS.

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