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Exosomes in Cancer: Diagnostic and Therapeutic Applications

Overview
Publisher Sage Publications
Specialty Oncology
Date 2024 Jan 22
PMID 38249520
Authors
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Abstract

Small extracellular vesicles called exosomes are produced by cells and contain a range of biomolecules, including proteins, lipids, and nucleic acids. Exosomes have been implicated in the development and spread of cancer, and recent studies have shown that their contents may be exploited as biomarkers for early detection and ongoing surveillance of the disease. In this review article, we summarize the current knowledge on exosomes as biomarkers of cancer. We discuss the various methods used for exosome isolation and characterization, as well as the different types of biomolecules found within exosomes that are relevant for cancer diagnosis and prognosis. We also highlight recent studies that have demonstrated the utility of exosomal biomarkers in different types of cancer, such as lung cancer, breast cancer, and pancreatic cancer. Overall, exosomes show great promise as noninvasive biomarkers for cancer detection and monitoring. Exosomes have the ability to transform cancer diagnostic and therapeutic paradigms, providing promise for more efficient and individualized. This review seeks to serve as an inspiration for new ideas and research in the never-ending fight against cancer. Moreover, further studies are needed to validate their clinical utility and establish standardized protocols for their isolation and analysis. With continued research and development, exosomal biomarkers have the potential to revolutionize cancer diagnosis and treatment.

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References
1.
El Andaloussi S, Mager I, Breakefield X, Wood M . Extracellular vesicles: biology and emerging therapeutic opportunities. Nat Rev Drug Discov. 2013; 12(5):347-57. DOI: 10.1038/nrd3978. View

2.
Pylayeva-Gupta Y, Grabocka E, Bar-Sagi D . RAS oncogenes: weaving a tumorigenic web. Nat Rev Cancer. 2011; 11(11):761-74. PMC: 3632399. DOI: 10.1038/nrc3106. View

3.
Cheng N, Du D, Wang X, Liu D, Xu W, Luo Y . Recent Advances in Biosensors for Detecting Cancer-Derived Exosomes. Trends Biotechnol. 2019; 37(11):1236-1254. DOI: 10.1016/j.tibtech.2019.04.008. View

4.
Wrana F, Dotzer K, Prufer M, Werner J, Mayer B . High Dual Expression of the Biomarkers CD44v6/α2β1 and CD44v6/PD-L1 Indicate Early Recurrence after Colorectal Hepatic Metastasectomy. Cancers (Basel). 2022; 14(8). PMC: 9027562. DOI: 10.3390/cancers14081939. View

5.
Szajnik M, Czystowska-Kuzmicz M, Elishaev E, Whiteside T . Biological markers of prognosis, response to therapy and outcome in ovarian carcinoma. Expert Rev Mol Diagn. 2016; 16(8):811-26. PMC: 5010004. DOI: 10.1080/14737159.2016.1194758. View