Myocardial Calcium Handling in Type 2 Diabetes: A Novel Therapeutic Target

Overview

Journal J Cardiovasc Dev Dis

Specialty Cardiology & Vascular Diseases

Date 2024 Jan 22

PMID 38248882

Authors

Abhishek Dattani

Anvesha Singh

Gerry P McCann

Gaurav S Gulsin

Affiliations

Soon will be listed here.

Abstract

Type 2 diabetes (T2D) is a multisystem disease with rapidly increasing global prevalence. Heart failure has emerged as a major complication of T2D. Dysregulated myocardial calcium handling is evident in the failing heart and this may be a key driver of cardiomyopathy in T2D, but until recently this has only been demonstrated in animal models. In this review, we describe the physiological concepts behind calcium handling within the cardiomyocyte and the application of novel imaging techniques for the quantification of myocardial calcium uptake. We take an in-depth look at the evidence for the impairment of calcium handling in T2D using pre-clinical models as well as in vivo studies, following which we discuss potential novel therapeutic approaches targeting dysregulated myocardial calcium handling in T2D.

Citing Articles

Molecular Basis of Cardiomyopathies in Type 2 Diabetes.

Giardinelli S, Meliota G, Mentino D, DAmato G, Faienza M Int J Mol Sci. 2024; 25(15).

PMID: 39125850 PMC: 11313011. DOI: 10.3390/ijms25158280.

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