Metabolic Regulations of L. Against β-Amyloid Toxicity in

Overview

Journal Metabolites

Publisher MDPI

Date 2024 Jan 22

PMID 38248852

Authors

Lili Yan

Yuchan Deng

Yulan Du

Xutong Fang

Xin Fang

Qiang Zhang

Affiliations

Soon will be listed here.

Abstract

L. (Chinaroot) is a natural herb that has multiple uses, such as being used to make tea and food. Both its roots and leaves have different uses due to their unique components. In this study, we analyzed the extract of roots using LC-HRMS and evaluated the neuroprotective effects and metabolic regulation of on Chinaroot extract prolonged the life span of healthy nematodes, delayed the paralysis time of transgenic CL4176, and reduced the level of β-amyloid deposition in transgenic CL2006. The comprehensive analysis of metabolomics and qRT-PCR revealed that Chinaroot extract exerted neuroprotective effects through the valine, leucine and isoleucine degradation and fatty acid degradation pathways. Moreover, we first discovered that the expressions of , , and were linked to the neuroprotective effects of Chinaroot. The material exerted neuroprotective effects by modulating metabolic abnormalities in AD model . Our study provides a new foundation for the development of functional food properties and functions.

References

Ban J, Cho S, Koh S, Song K, Bae K, Seong Y . Protection of amyloid beta protein (25-35)-induced neurotoxicity by methanol extract of Smilacis chinae rhizome in cultured rat cortical neurons. J Ethnopharmacol. 2006; 106(2):230-7. DOI: 10.1016/j.jep.2005.12.034. View

Vesga-Jimenez D, Martin C, Barreto G, Aristizabal-Pachon A, Pinzon A, Gonzalez J . Fatty Acids: An Insight into the Pathogenesis of Neurodegenerative Diseases and Therapeutic Potential. Int J Mol Sci. 2022; 23(5). PMC: 8910658. DOI: 10.3390/ijms23052577. View

Khan M, Khan Z, Shoeb F, Fatima G, Khan R, Khan M . Role of de novo lipogenesis in inflammation and insulin resistance in Alzheimer's disease. Int J Biol Macromol. 2023; 242(Pt 2):124859. DOI: 10.1016/j.ijbiomac.2023.124859. View

Ding J, Ji J, Rabow Z, Shen T, Folz J, Brydges C . A metabolome atlas of the aging mouse brain. Nat Commun. 2021; 12(1):6021. PMC: 8519999. DOI: 10.1038/s41467-021-26310-y. View

Cai Y, Du J, Li A, Zhu Y, Xu L, Sun K . Initial levels of β-amyloid and tau deposition have distinct effects on longitudinal tau accumulation in Alzheimer's disease. Alzheimers Res Ther. 2023; 15(1):30. PMC: 9903587. DOI: 10.1186/s13195-023-01178-w. View

Song X, Sun Y, Wang Z, Su Y, Wang Y, Wang X . Exendin-4 alleviates β-Amyloid peptide toxicity DAF-16 in a model of Alzheimer's disease. Front Aging Neurosci. 2022; 14:955113. PMC: 9389237. DOI: 10.3389/fnagi.2022.955113. View

Wang M, Bai Q, Zheng X, Hu W, Wang S, Tang H . Smilax china L.: A review of its botany, ethnopharmacology, phytochemistry, pharmacological activities, actual and potential applications. J Ethnopharmacol. 2023; 318(Pt B):116992. DOI: 10.1016/j.jep.2023.116992. View

Olgiati S, Skorvanek M, Quadri M, Minneboo M, Graafland J, Breedveld G . Paroxysmal exercise-induced dystonia within the phenotypic spectrum of ECHS1 deficiency. Mov Disord. 2016; 31(7):1041-8. DOI: 10.1002/mds.26610. View

Zheng R, Li Y, Wang L, Fang X, Zhang J, He L . CRISPR/Cas9-mediated metabolic pathway reprogramming in a novel humanized rat model ameliorates primary hyperoxaluria type 1. Kidney Int. 2020; 98(4):947-957. DOI: 10.1016/j.kint.2020.04.049. View

10.

He P, Yan S, Zheng J, Gao Y, Zhang S, Liu Z . Eriodictyol Attenuates LPS-Induced Neuroinflammation, Amyloidogenesis, and Cognitive Impairments via the Inhibition of NF-κB in Male C57BL/6J Mice and BV2 Microglial Cells. J Agric Food Chem. 2018; 66(39):10205-10214. DOI: 10.1021/acs.jafc.8b03731. View

11.

Sakamoto T, Cansev M, Wurtman R . Oral supplementation with docosahexaenoic acid and uridine-5'-monophosphate increases dendritic spine density in adult gerbil hippocampus. Brain Res. 2007; 1182:50-9. PMC: 2140951. DOI: 10.1016/j.brainres.2007.08.089. View

12.

Ban J, Cho S, Jeon S, Bae K, Song K, Seong Y . 3,4-dihydroxybenzoic acid from Smilacis chinae rhizome protects amyloid beta protein (25-35)-induced neurotoxicity in cultured rat cortical neurons. Neurosci Lett. 2007; 420(2):184-8. DOI: 10.1016/j.neulet.2007.05.009. View

13.

Du F, Zhao H, Yao M, Yang Y, Jiao J, Li C . Deer antler extracts reduce amyloid-beta toxicity in a Caenorhabditis elegans model of Alzheimer's disease. J Ethnopharmacol. 2021; 285:114850. DOI: 10.1016/j.jep.2021.114850. View

14.

Aydogan C . Recent advances and applications in LC-HRMS for food and plant natural products: a critical review. Anal Bioanal Chem. 2020; 412(9):1973-1991. DOI: 10.1007/s00216-019-02328-6. View

15.

Ozlu C, Chelliah P, Dahshi H, Horton D, Edgar V, Messahel S . ECHS1 deficiency and its biochemical and clinical phenotype. Am J Med Genet A. 2022; 188(10):2908-2919. DOI: 10.1002/ajmg.a.62895. View

16.

Chen L, Yin H, Lan Z, Ma S, Zhang C, Yang Z . Anti-hyperuricemic and nephroprotective effects of Smilax china L. J Ethnopharmacol. 2011; 135(2):399-405. DOI: 10.1016/j.jep.2011.03.033. View

17.

Suelves N, Saleki S, Ibrahim T, Palomares D, Moonen S, Koper M . Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-β accumulation in a mouse model of amyloid pathology. Acta Neuropathol Commun. 2023; 11(1):82. PMC: 10189946. DOI: 10.1186/s40478-023-01578-x. View

18.

Sanchez-Martinez J, Cifuentes A, Valdes A . Omics approaches to investigate the neuroprotective capacity of a Citrus sinensis (sweet orange) extract in a Caenorhabditis elegans Alzheimer's model. Food Res Int. 2023; 172:113128. DOI: 10.1016/j.foodres.2023.113128. View

19.

Anand A, Khurana N, Kaur S, Ali N, Alasmari A, Waseem M . The multifactorial role of vanillin in amelioration of aluminium chloride and D-galactose induced Alzheimer's disease in mice. Eur J Pharmacol. 2023; 954:175832. DOI: 10.1016/j.ejphar.2023.175832. View

20.

Altine-Samey R, Antier D, Mavel S, Dufour-Rainfray D, Balageas A, Beaufils E . The contributions of metabolomics in the discovery of new therapeutic targets in Alzheimer's disease. Fundam Clin Pharmacol. 2021; 35(3):582-594. DOI: 10.1111/fcp.12654. View