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Vitiligo: Current Therapies and Future Treatments

Overview
Journal Dermatol Pract Concept
Specialty Dermatology
Date 2024 Jan 19
PMID 38241396
Authors
Julien Seneschal
Katia Boniface
Affiliations
Soon will be listed here.
Abstract

The current management of vitiligo remains challenging; however, different strategies can be proposed to patients with a good efficacy in many cases. First, it is important to identify patients in the active phase of the disease because treatment should start as soon as possible to halt its progression. For patients with a stable disease, the treatment strategy is now well-stratified and is based on a combination of phototherapy (natural or in a cabin) and topical immunomodulatory agents. Surgical treatments are useful for localized and stable vitiligo, as well as for segmental vitiligo. Depigmentation remains indicated in very extensive forms. The recent approval of topical ruxolitinib cream in both the US and Europe brings new approaches for the management of vitiligo and paves the way for the development of new topical or oral targeted drugs.

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References
1.
Esmat S, Mostafa W, Hegazy R, Shalaby S, Sheth V, Youssef R . Phototherapy: The vitiligo management pillar. Clin Dermatol. 2016; 34(5):594-602. DOI: 10.1016/j.clindermatol.2016.05.009. View
2.
Seneschal J, Speeckaert R, Taieb A, Wolkerstorfer A, Passeron T, Pandya A . Worldwide expert recommendations for the diagnosis and management of vitiligo: Position statement from the international Vitiligo Task Force-Part 2: Specific treatment recommendations. J Eur Acad Dermatol Venereol. 2023; 37(11):2185-2195. DOI: 10.1111/jdv.19450. View
3.
Esmat S, El-Mofty M, Rasheed H, Mostafa W, Anbar T, Abdallah M . Efficacy of narrow band UVB with or without OMP in stabilization of vitiligo activity in skin photo-types (III-V): A double-blind, randomized, placebo-controlled, prospective, multicenter study. Photodermatol Photoimmunol Photomed. 2021; 38(3):277-287. DOI: 10.1111/phpp.12749. View
4.
van Geel N, Speeckaert R, Taieb A, Ezzedine K, Lim H, Pandya A . Worldwide expert recommendations for the diagnosis and management of vitiligo: Position statement from the International Vitiligo Task Force Part 1: towards a new management algorithm. J Eur Acad Dermatol Venereol. 2023; 37(11):2173-2184. DOI: 10.1111/jdv.19451. View
5.
Richmond J, Strassner J, Zapata Jr L, Garg M, Riding R, Refat M . Antibody blockade of IL-15 signaling has the potential to durably reverse vitiligo. Sci Transl Med. 2018; 10(450). PMC: 6495055. DOI: 10.1126/scitranslmed.aam7710. View