The Atypical Organization of the Family Genes in AHL-driven Quorum-sensing Circuits

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 2024 Jan 19

PMID 38240569

Authors

Yuyuan Cai

Xuehong Zhang

Affiliations

Soon will be listed here.

Abstract

Quorum sensing (QS) is an elaborate regulatory mechanism associated with virulence and bacterial adaptation to the changing environment. QS is widespread in and acts primarily through -acylhomoserine lactone (AHL) signals. At the core of the AHL-driven QS systems are the AHL synthase gene ( family) and its cognate transcriptional regulator gene ( family). Several QS systems display one or more genes intervening between the , in which gene arrangements are notably different due to the relative position and the transcriptional orientation between the essential and the genes of location correlation. These adjacent genes may exert a regulatory impact on the primary QS genes or contribute toward an extension of QS regulatory control. In this review, we describe the organization of AHL-driven QS genes based on previous research and specific genome databases and provide new insights into these atypical QS gene arrangements.

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