Impact of Exercise Training on Gut Microbiome Imbalance in Obese Individuals: a Study Based on Mendelian Randomization Analysis

Overview

Journal Front Physiol

Date 2024 Jan 18

PMID 38235382

Authors

Haonan Qian

Yuxin Zuo

Shixiong Wen

Xilong Wang

Yaowen Liu

Tianwei Li

Affiliations

Soon will be listed here.

Abstract

The aim of this study was to investigate the relationship between exercise and gut Microbiome and to assess its possible causality. Using Mendelian randomization (MR) research methods, we collected genetic data from different populations, including genetic variants associated with relative abundance or presence of microbial taxa as instrumental variables. At the same time, we extracted results related to obesity and gut Microbiome from existing relevant studies and used inverse variance weighting (IVW), weighted median, and MR-Egger regression to assess the causal relationship between obesity and gut Microbiome. We plotted forest plots and scatter plots of the association between obesity and gut Microbiome. Gut Microbiome was positively associated with obesity, and four bacterial genera (Akkermansia, RuminococcaceaeUCG011, Holdemania, and Intestinimonas) were associated with obesity according to inverse variance-weighted estimation in at least one MR method. Inverse variance weighted estimation showed that obesity was associated with obesity in Akkermansia (OR = 0.810, 95% CI 0.608-1.079, = 0.04), RuminococcaceaeUCG011 (OR = 1.238, 95% CI 0. 511-2.999, = 0.04), Holdemania Intestinimonas (OR = 1.214, 95% CI 1.002-1.470, = 0.03), and Intestinimonas (OR = 0.747, 95% CI 0.514-1.086, = 0.01) had a relevant effect. Obesity decreased the abundance of Akkermansia, Intestinimonas microbiome and increased the abundance of RuminococcaceaeUCG011, Holdemania microbiome. The results of this study, conducted using a two-sample Mendelian randomization method, suggest a causal relationship between obesity and intestinal microbiome. Obesity decreased the abundance of Akkermansia, Intestinimonas microbiome and increased the abundance of RuminococcaceaeUCG011, Holdemania microbiome. More randomized controlled trials are necessary to elucidate the protective effects of exercise on gut Microbiome and its unique protective mechanisms.

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References

Martinez-Lopez Y, Esquivel-Hernandez D, Sanchez-Castaneda J, Neri-Rosario D, Guardado-Mendoza R, Resendis-Antonio O . Type 2 diabetes, gut microbiome, and systems biology: A novel perspective for a new era. Gut Microbes. 2022; 14(1):2111952. PMC: 9423831. DOI: 10.1080/19490976.2022.2111952. View

Ray K . Gut microbiota. Tackling the effects of diet and exercise on the gut microbiota. Nat Rev Gastroenterol Hepatol. 2014; 11(8):456. DOI: 10.1038/nrgastro.2014.109. View

Xia W, Xu M, Yu X, Du M, Li X, Yang T . Antihypertensive effects of exercise involve reshaping of gut microbiota and improvement of gut-brain axis in spontaneously hypertensive rat. Gut Microbes. 2020; 13(1):1-24. PMC: 7781639. DOI: 10.1080/19490976.2020.1854642. View

Sales K, Reimer R . Unlocking a novel determinant of athletic performance: The role of the gut microbiota, short-chain fatty acids, and "biotics" in exercise. J Sport Health Sci. 2022; 12(1):36-44. PMC: 9923434. DOI: 10.1016/j.jshs.2022.09.002. View

Wegierska A, Charitos I, Topi S, Potenza M, Montagnani M, Santacroce L . The Connection Between Physical Exercise and Gut Microbiota: Implications for Competitive Sports Athletes. Sports Med. 2022; 52(10):2355-2369. PMC: 9474385. DOI: 10.1007/s40279-022-01696-x. View

Lai Z, Shan W, Li J, Min J, Zeng X, Zuo Z . Appropriate exercise level attenuates gut dysbiosis and valeric acid increase to improve neuroplasticity and cognitive function after surgery in mice. Mol Psychiatry. 2021; 26(12):7167-7187. PMC: 8873004. DOI: 10.1038/s41380-021-01291-y. View

Morita H, Kano C, Ishii C, Kagata N, Ishikawa T, Hirayama A . and its preferred substrate, α-cyclodextrin, enhance endurance exercise performance in mice and human males. Sci Adv. 2023; 9(4):eadd2120. PMC: 9876546. DOI: 10.1126/sciadv.add2120. View

Aron-Wisnewsky J, Warmbrunn M, Nieuwdorp M, Clement K . Nonalcoholic Fatty Liver Disease: Modulating Gut Microbiota to Improve Severity?. Gastroenterology. 2020; 158(7):1881-1898. DOI: 10.1053/j.gastro.2020.01.049. View

Carmody R, Bisanz J . Roles of the gut microbiome in weight management. Nat Rev Microbiol. 2023; 21(8):535-550. DOI: 10.1038/s41579-023-00888-0. View

10.

Seke Etet P, Vecchio L, Nwabo Kamdje A, Mimche P, Njamnshi A, Adem A . Physiological and environmental factors affecting cancer risk and prognosis in obesity. Semin Cancer Biol. 2023; 94:50-61. DOI: 10.1016/j.semcancer.2023.06.002. View

11.

Liu C, Cheung W, Li J, Chow S, Yu J, Wong S . Understanding the gut microbiota and sarcopenia: a systematic review. J Cachexia Sarcopenia Muscle. 2021; 12(6):1393-1407. PMC: 8718038. DOI: 10.1002/jcsm.12784. View

12.

Wang C, Bai J, Chen X, Song J, Zhang Y, Wang H . Gut microbiome-based strategies for host health and disease. Crit Rev Food Sci Nutr. 2023; 64(19):6834-6849. DOI: 10.1080/10408398.2023.2176464. View

13.

Van Hul M, Cani P . The gut microbiota in obesity and weight management: microbes as friends or foe?. Nat Rev Endocrinol. 2023; 19(5):258-271. DOI: 10.1038/s41574-022-00794-0. View

14.

Yang Z, Wang Q, Liu Y, Wang L, Ge Z, Li Z . Gut microbiota and hypertension: association, mechanisms and treatment. Clin Exp Hypertens. 2023; 45(1):2195135. DOI: 10.1080/10641963.2023.2195135. View

15.

Zhou Q, Deng J, Pan X, Meng D, Zhu Y, Bai Y . Gut microbiome mediates the protective effects of exercise after myocardial infarction. Microbiome. 2022; 10(1):82. PMC: 9153113. DOI: 10.1186/s40168-022-01271-6. View

16.

Barton W, Penney N, Cronin O, Garcia-Perez I, Molloy M, Holmes E . The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level. Gut. 2017; 67(4):625-633. DOI: 10.1136/gutjnl-2016-313627. View

17.

Arnoriaga-Rodriguez M, Mayneris-Perxachs J, Contreras-Rodriguez O, Burokas A, Ortega-Sanchez J, Blasco G . Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways. Gut. 2021; 70(12):2283-2296. PMC: 8588299. DOI: 10.1136/gutjnl-2020-323371. View

18.

Della Guardia L, Codella R . Exercise tolls the bell for key mediators of low-grade inflammation in dysmetabolic conditions. Cytokine Growth Factor Rev. 2021; 62:83-93. DOI: 10.1016/j.cytogfr.2021.09.003. View

19.

Cheng R, Wang L, LE S, Yang Y, Zhao C, Zhang X . A randomized controlled trial for response of microbiome network to exercise and diet intervention in patients with nonalcoholic fatty liver disease. Nat Commun. 2022; 13(1):2555. PMC: 9091228. DOI: 10.1038/s41467-022-29968-0. View

20.

Wei S, Brejnrod A, Trivedi U, Steen Mortensen M, Johansen M, Karstoft K . Impact of intensive lifestyle intervention on gut microbiota composition in type 2 diabetes: a analysis of a randomized clinical trial. Gut Microbes. 2021; 14(1):2005407. PMC: 8726663. DOI: 10.1080/19490976.2021.2005407. View