Article: | MedLuna.com

Overview

Journal Am J Physiol Renal Physiol

Publisher American Physiological Society

Specialties Nephrology
Physiology

Date 2024 Jan 18

PMID 38234297

Authors

Carlos A Roncal-Jimenez

Keegan L Rogers

Arthur Stem

Julia Wijkstrom

Annika Wernerson

Jacob Fox

Ramon Garcia Trabanino

Stephen Brindley

Gabriela Garcia

Makoto Miyazaki

Shinobu Miyazaki-Anzai

Fumihiko Sasai

Manuel Urra

Gabriel Cara-Fuentes

L Gabriela Sanchez-Lozada

Bernardo Rodriguez-Iturbe

Jaime Butler Dawson

Magdalena Madero

Jared M Brown

Richard J Johnson

Affiliations

Soon will be listed here.

Abstract

Silica nanoparticles found in sugarcane ash have been postulated to be a toxicant contributing to chronic kidney disease of unknown etiology (CKDu). However, while the administration of manufactured silica nanoparticles is known to cause chronic tubulointerstitial disease in rats, the effect of administering sugarcane ash on kidney pathology remains unknown. Here we investigate whether sugarcane ash can induce CKD in rats. . Sugarcane ash was administered for 13 weeks into the nares of rats (5 mg/day for 5d/week), and blood, urine and kidney tissues were collected at 13 weeks (at the end of ash administration) and in a separate group of rats at 24 weeks (11 weeks after stopping ash administration). Kidney histology was evaluated, and inflammation and fibrosis (collagen deposition) measured. . Sugarcane ash exposure led to the accumulation of silica in the kidneys, lungs, liver and spleen of rats. Mild proteinuria developed although renal function was largely maintained. However, biopsies showed focal glomeruli with segmental glomerulosclerosis, and tubulointerstitial inflammation and fibrosis that tended to worsen even after the ash administration had been stopped. Staining for the lysosomal marker, LAMP-1, showed decreased staining in ash administered rats consistent with lysosomal activation. . Sugarcane ash containing silica nanoparticles can cause CKD in rats.

Citing Articles

Modulation of the thiol redox proteome by sugarcane ash-derived silica nanoparticles: insights into chronic kidney disease of unknown etiology.

Stem A, Michel C, Harris P, Rogers K, Gibb M, Roncal-Jimenez C Part Fibre Toxicol. 2025; 22(1):3.

PMID: 39910563 PMC: 11800628. DOI: 10.1186/s12989-025-00619-8.

The Adverse Health Effects of Air Pollution from Sugarcane Burning: A Scoping Review of Observational and Experimental Evidence.

Manrique A, Clarke K, Bisesi S, Arosemena F, Coker E, Sabo-Attwood T Environ Health Perspect. 2025; 133(1):16002.

PMID: 39883532 PMC: 11781560. DOI: 10.1289/EHP14456.

The Promise of Metabolomics and Exposomics in CKDu.

Raines N, Rodriguez Garcia E Kidney Int Rep. 2024; 9(5):1163-1166.

PMID: 38707828 PMC: 11069007. DOI: 10.1016/j.ekir.2024.03.025.

Health burden of sugarcane burning on agricultural workers and nearby communities.

Stem A, Gibb M, Roncal-Jimenez C, Johnson R, Brown J Inhal Toxicol. 2024; 36(5):327-342.

PMID: 38349733 PMC: 11260540. DOI: 10.1080/08958378.2024.2316875.

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