Skin Rejuvenation in Women Using Menopausal Hormone Therapy: A Systematic Review and Meta-Analysis

Overview

Journal J Menopausal Med

Date 2024 Jan 17

PMID 38230593

Authors

Laura Pivazyan

Julietta Avetisyan

Maria Loshkareva

Amina Abdurakhmanova

Affiliations

Soon will be listed here.

Abstract

Objectives: To evaluate the effect of menopausal hormone therapy (MHT) on skin aging in menopausal women.

Methods: Studies were identified by searching PubMed, Cochrane Library, Google Scholar, and ClinicalTrials.gov databases using the key words "hormone replacement therapy" AND "skin" AND "menopausal." Studies that used and compared oral/transdermal MHT with placebo or another type of treatment in menopausal women aged 45-55 years were selected.

Results: From 1,526 studies identified, 15 studies comprising 1,589 patients were included in the final analysis. Our meta-analysis aimed to compare skin elasticity (standard [Std] mean difference = 0.28; 95% confidence interval [CI], 0.03-0.54; = 0.03), skin thickness (Std. mean difference = 1.27; 95% CI, 0.88-1.66; < 0.00001), collagen content (Std. mean difference = 2.01; 95% CI, 1.42-2.61; < 0.00001), and skin dryness (Std. mean difference = 0.15; 95% CI, -0.05 to 0.35; = 0.14).

Conclusions: MHT increases elasticity and collagen content in the skin, thereby reducing the severity of wrinkles and increasing skin thickness. Nevertheless, more well-conducted clinical trials are required to answer all questions in an evidence-based manner.

References

Haapasaari K, Raudaskoski T, Kallioinen M, Kauppila A, Laara E, Risteli J . Systemic therapy with estrogen or estrogen with progestin has no effect on skin collagen in postmenopausal women. Maturitas. 1997; 27(2):153-62. DOI: 10.1016/s0378-5122(97)01128-6. View

Baber R, Panay N, Fenton A . 2016 IMS Recommendations on women's midlife health and menopause hormone therapy. Climacteric. 2016; 19(2):109-50. DOI: 10.3109/13697137.2015.1129166. View

de Villiers T, Hall J, Pinkerton J, Cerdas Perez S, Rees M, Yang C . Revised Global Consensus Statement on Menopausal Hormone Therapy. Climacteric. 2016; 19(4):313-5. DOI: 10.1080/13697137.2016.1196047. View

Braverman I, Fonferko E . Studies in cutaneous aging: I. The elastic fiber network. J Invest Dermatol. 1982; 78(5):434-43. DOI: 10.1111/1523-1747.ep12507866. View

Pierard-Franchimont C, Cornil F, Dehavay J, Deleixhe-Mauhin F, Letot B, Pierard G . Climacteric skin ageing of the face--a prospective longitudinal comparative trial on the effect of oral hormone replacement therapy. Maturitas. 1999; 32(2):87-93. DOI: 10.1016/s0378-5122(99)00019-5. View

Castelo-Branco C, Duran M, Gonzalez-Merlo J . Skin collagen changes related to age and hormone replacement therapy. Maturitas. 1992; 15(2):113-9. DOI: 10.1016/0378-5122(92)90245-y. View

Pierard G, Hermanns-Le T, Paquet P, Pierard-Franchimont C . Skin viscoelasticity during hormone replacement therapy for climacteric ageing. Int J Cosmet Sci. 2013; 36(1):88-92. DOI: 10.1111/ics.12100. View

Sator P, Sator M, Schmidt J, Nahavandi H, Radakovic S, Huber J . A prospective, randomized, double-blind, placebo-controlled study on the influence of a hormone replacement therapy on skin aging in postmenopausal women. Climacteric. 2007; 10(4):320-34. DOI: 10.1080/13697130701444073. View

Creidi P, Faivre B, Agache P, Richard E, Haudiquet V, Sauvanet J . Effect of a conjugated oestrogen (Premarin) cream on ageing facial skin. A comparative study with a placebo cream. Maturitas. 1994; 19(3):211-23. DOI: 10.1016/0378-5122(94)90074-4. View

10.

Fuchs K, Solis O, Tapawan R, Paranjpe J . The effects of an estrogen and glycolic acid cream on the facial skin of postmenopausal women: a randomized histologic study. Cutis. 2003; 71(6):481-8. View

11.

Hill M, Cartron A, Burgoyne M, Driscoll M . Hormone therapy and melanoma in women. Int J Womens Dermatol. 2022; 7(5Part B):692-696. PMC: 8714603. DOI: 10.1016/j.ijwd.2021.06.005. View

12.

Herman J, Rost-Roszkowska M, Skotnicka-Graca U . Skin care during the menopause period: noninvasive procedures of beauty studies. Postepy Dermatol Alergol. 2014; 30(6):388-95. PMC: 3907896. DOI: 10.5114/pdia.2013.39430. View

13.

Pierard G, Letawe C, Dowlati A, Pierard-Franchimont C . Effect of hormone replacement therapy for menopause on the mechanical properties of skin. J Am Geriatr Soc. 1995; 43(6):662-5. DOI: 10.1111/j.1532-5415.1995.tb07202.x. View

14.

Pierard G, Vanderplaetsen S, Pierard-Franchimont C . Comparative effect of hormone replacement therapy on bone mass density and skin tensile properties. Maturitas. 2001; 40(3):221-7. DOI: 10.1016/s0378-5122(01)00241-9. View

15.

Burger H, Hale G, Robertson D, Dennerstein L . A review of hormonal changes during the menopausal transition: focus on findings from the Melbourne Women's Midlife Health Project. Hum Reprod Update. 2007; 13(6):559-65. DOI: 10.1093/humupd/dmm020. View

16.

Holzer G, Riegler E, Honigsmann H, Farokhnia S, Schmidt J, Schmidt B . Effects and side-effects of 2% progesterone cream on the skin of peri- and postmenopausal women: results from a double-blind, vehicle-controlled, randomized study. Br J Dermatol. 2005; 153(3):626-34. DOI: 10.1111/j.1365-2133.2005.06685.x. View

17.

Reus T, Brohem C, Schuck D, Lorencini M . Revisiting the effects of menopause on the skin: Functional changes, clinical studies, in vitro models and therapeutic alternatives. Mech Ageing Dev. 2019; 185:111193. DOI: 10.1016/j.mad.2019.111193. View

18.

Page M, McKenzie J, Bossuyt P, Boutron I, Hoffmann T, Mulrow C . The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021; 372:n71. PMC: 8005924. DOI: 10.1136/bmj.n71. View

19.

Maheux R, Naud F, Rioux M, Grenier R, Lemay A, Guy J . A randomized, double-blind, placebo-controlled study on the effect of conjugated estrogens on skin thickness. Am J Obstet Gynecol. 1994; 170(2):642-9. DOI: 10.1016/s0002-9378(94)70242-x. View

20.

Lovell C, Smolenski K, Duance V, Light N, Young S, Dyson M . Type I and III collagen content and fibre distribution in normal human skin during ageing. Br J Dermatol. 1987; 117(4):419-28. DOI: 10.1111/j.1365-2133.1987.tb04921.x. View