X-linked Hypophosphatemia, Fibroblast Growth Factor 23 Signaling, and Craniosynostosis

Overview

Journal Exp Biol Med (Maywood)

Specialty Biology

Date 2024 Jan 17

PMID 38230523

Authors

Chelsey Grimbly

Daniel Graf

Leanne M Ward

R Todd Alexander

Affiliations

Soon will be listed here.

Abstract

This review summarizes the current knowledge of fibroblast growth factor 23 signaling in bone and its role in the disease pathology of X-linked hypophosphatemia. Craniosynostosis is an under-recognized complication of X-linked hypophosphatemia. The clinical implications and potential cellular mechanisms invoked by increased fibroblast growth factor 23 signaling causing craniosynostosis are reviewed. Knowledge gaps are identified and provide direction for future clinical and basic science studies.

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