Pathological Markers of Alzheimer's Disease and Related Dementia in the Rhesus Macaque Amygdala

Overview

Journal J Alzheimers Dis Rep

Publisher IOS Press

Date 2024 Jan 17

PMID 38229831

Authors

Jeremy L Thomas

Benjamin I Nilaver

Alejandro Lomniczi

Donald I Brown

Maria-Luisa Appleman

Steven G Kohama

Henryk F Urbanski

Affiliations

Soon will be listed here.

Abstract

Rhesus macaques develop amyloid-β (Aβ) plaques during old age, but it is unclear how extensively they express other pathological hallmarks of dementia. Here we used immunohistochemistry to examine expression of phosphorylated tau (pTau) protein and cytoplasmic inclusions of TAR DNA binding protein 43 kDa (TDP-43) within the amygdala of young and old males, and also in old surgically-menopausal females that were maintained on regular or obesogenic diets. Only one animal, a 23-year-old female, showed pTau expression and none showed TDP-43 inclusions. What genetic and/or environmental factors protect macaques from expressing more severe human neuro-pathologies remains an interesting unresolved question.

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