Relationship Between Long Non-coding RNAs and Hippo Signaling Pathway in Gastrointestinal Cancers; Molecular Mechanisms and Clinical Significance

Overview

Journal Heliyon

Specialty Social Sciences

Date 2024 Jan 16

PMID 38226210

Authors

Farimah Fayyaz

Zahra Shokati Eshkiki

Amir Reza Karamzadeh

Zahra Moradi

Faezeh Kaviani

Abolfazl Namazi

Roya Karimi

Seidamir Pasha Tabaeian

Fatemeh Mansouri

Abolfazl Akbari

Affiliations

Soon will be listed here.

Abstract

Long non-coding RNAs (lncRNAs) play a significant biological role in the regulation of various cellular processes such as cell proliferation, differentiation, apoptosis and migration. In various malignancies, lncRNAs interplay with some main cancer-associated signaling pathways, including the Hippo signaling pathway to regulate the various cellular processes. It has been revealed that the cross-talking between lncRNAs and Hippo signaling pathway involves in gastrointestinal (GI) cancers development and progression. Considering the clinical significance of these lncRNAs, they have also been introduced as potential biomarkers in diagnostic, prognostic and therapeutic strategies in GI cancers. Herein, we review the mechanisms of lncRNA-mediated regulation of Hippo signaling pathway and focus on the corresponding molecular mechanisms and clinical significance of these non-coding RNAs in GI cancers.

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