SARS-CoV-2 Biology and Host Interactions

Overview

Journal Nat Rev Microbiol

Specialties Infectious Diseases
Microbiology

Date 2024 Jan 15

PMID 38225365

Authors

Silvio Steiner

Annika Kratzel

G Tuba Barut

Reto M Lang

Etori Aguiar Moreira

Lisa Thomann

Jenna N Kelly

Volker Thiel

Affiliations

Soon will be listed here.

Abstract

The zoonotic emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected our society. The rapid spread and continuous evolution of new SARS-CoV-2 variants continue to threaten global public health. Recent scientific advances have dissected many of the molecular and cellular mechanisms involved in coronavirus infections, and large-scale screens have uncovered novel host-cell factors that are vitally important for the virus life cycle. In this Review, we provide an updated summary of the SARS-CoV-2 life cycle, gene function and virus-host interactions, including recent landmark findings on general aspects of coronavirus biology and newly discovered host factors necessary for virus replication.

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