Anticancer Effects of Herbal Medicine Emelia-M, Mshikazi and Delosma H Against Human Leukaemia Cells

Overview

Journal Afr Health Sci

Date 2024 Jan 15

PMID 38223600

Authors

Joy Nkechinyere Adeniyi

Manimbulu Nlooto

Mlungisi Ngcobo

Roshila Moodley

Exnevia Gomo

Affiliations

Soon will be listed here.

Abstract

Background: Leukaemia is one of the three major types of blood cancers that lead to the overproduction of abnormal white blood cells. (EMB), and are herbal medicines that are being used by traditional healers in KwaZulu-Natal, South Africa to treat leukaemia and other diseases.

Objectives: To gain insight into the safety (non-toxic effect), anti-cancer activity, mechanisms of action and phytochemical profiles of traditional herbal medicines and in South Africa.

Methods: The viability of human peripheral blood mononuclear cells (PBMCs), monocytic (THP-1) and T-lymphocyte (Jurkat) cell lines exposed to varying concentrations of aqueous extracts of the three herbal medicines were assessed using adenosine triphosphate (ATP) assay.

Results: All three extracts showed a dose-dependent effect on the viability of PBMCs. Cell viability decreased with increasing concentrations of extracts when compared with the untreated cells at 24 and 48 hours. The inhibitory activities (IC50) of the extract were found in the order of . All the extracts induced apoptosis with minimal necrosis. Many bioactive compounds that have been previously reported to have anticancer effects were identified in the extracts.

Conclusion: extract significantly inhibited the growth of THP-1 and Jurkat cells and induced cell death through apoptosis than the other two extracts.

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