Association Between Factor-V Leiden and Occurrence of Acute Myocardial Infarction Using a Large NIS Database

Overview

Journal Am J Blood Res

Specialty Hematology

Date 2024 Jan 15

PMID 38223312

Authors

Luis Zuniga

Mitchell Davis

Mohammad Reza Movahed

Mehrtash Hashemzadeh

Mehrnoosh Hashemzadeh

Affiliations

Soon will be listed here.

Abstract

Background: Medical literature regarding the correlation between Factor V Leiden (FVL) and acute myocardial infarctions (AMI) is controversial. We aim to investigate the association between FVL and AMI.

Materials And Methods: Using the Nationwide Inpatient Sample database, we evaluated any association between Factor V Leiden and acute myocardial infarction in 2016 using ICD-10 codes.

Results: Univariate analysis (18-40) showed an increase of AMI in patients with FVL 0.6% vs. 0.4%. However, after adjustment for age and comorbid conditions in multivariate analysis, FVL was not significantly associated with acute myocardial infarction (OR 1.44 (95% CI 0.913-2.273, -value 0.117)). Univariate analysis (all patients over 18 years old) found that 2.9% of patients with FVL experienced AMI vs. 4.4% without the mutation. Multivariate analysis of the entire population ultimately showed no correlation between FVL and AMI.

Conclusion: In a population over 18, Factor V Leiden did not correlate with an increased risk of acute myocardial infarction in our studied population.

Citing Articles

The impact of thrombophilia on in-hospital outcomes in patients with acute coronary syndrome: insights from the United States National Inpatient Sample.

Kwok C, Gibbs T, Majeed M, Borovac J, Will M, Schwarz K J Thromb Thrombolysis. 2025; 58(2):178-187.

PMID: 39954039 DOI: 10.1007/s11239-025-03068-4.

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