Associations Between Urinary Concentrations of Polycyclic Aromatic Hydrocarbons and Overactive Bladder in US Adults: Data from the National Health and Nutrition Examination Survey 2005-2016

Overview

Journal Urol Int

Publisher Karger

Specialty Urology

Date 2024 Jan 14

PMID 38219726

Authors

Shihang Pu

Qi Li

Zhijun Tao

Songbo Wang

XiangYu Meng

Shangqian Wang

Zengjun Wang

Affiliations

Soon will be listed here.

Abstract

Introduction: Polycyclic aromatic hydrocarbons (PAHs) are a group of chemicals that can induce oxidative stress and related cytotoxicity. Whether urinary concentrations of PAHs have effects on overactive bladder (OAB) in the general population is still unclear. This study investigated the associations between urinary PAHs and OAB.

Methods: 7,146 adults aged over 20 who participated in the US National Health and Nutrition Examination Survey 2005-2016 were studied. The impact of the six PAHs on OAB was evaluated by multivariate logistic regression, and percent changes related to different quartiles of those six PAH levels were calculated. Confounders including age, logarithmic urinary creatinine, gender, race, body mass index, educational level, marriage, poverty income ratio, diabetes, hypertension, and metabolic syndrome were controlled.

Results: There is a significant positive correlation between urinary concentrations of the six PAHs we include in the study and the occurrence of OAB. Furthermore, individuals with higher PAH levels also reported a more severe OAB symptom score (OABSS).

Conclusions: Our findings revealed that adult men in the USA with higher urinary PAHs had a higher risk of OAB incidence. These findings suggest the importance of strong environmental regulation of PAHs to protect population health. However, the underlying mechanisms still need further exploration.

Citing Articles

[Bladder training for treatment of overactive bladder in adults].

Schonburg S Urologie. 2024; 63(7):705-708.

PMID: 38844690 DOI: 10.1007/s00120-024-02368-6.

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