Extracellular Vesicle-mediated Ferroptosis, Pyroptosis, and Necroptosis: Potential Clinical Applications in Cancer Therapy

Overview

Journal Cell Death Discov

Date 2024 Jan 12

PMID 38216595

Authors

Yi-Chi Yang

Qian Jiang

Ke-Ping Yang

Lingzhi Wang

Gautam Sethi

Zhaowu Ma

Affiliations

Soon will be listed here.

Abstract

Extracellular vesicles (EVs) have gained increasing recognition as significant regulators of intercellular communication in various physiological and pathological processes. These vesicles play a pivotal role in cancer progression by facilitating the transfer of diverse cargoes, including lipids, proteins, and nucleic acids. Regulated cell death (RCD), the orderly and autonomous death of cells, is controlled by a variety of biomacromolecules and, in turn, influences various biological processes and cancer progression. Recent studies have demonstrated that EV cargoes regulate diverse oncogenes and tumor suppressors to mediate different nonapoptotic forms of RCD, notably ferroptosis, pyroptosis, and necroptosis. Nevertheless, comprehensive exploration of EV-mediated nonapoptotic RCD forms in the context of cancer has not been performed. This review summarizes the progress regarding the biological functions and underlying mechanisms of EVs in mediating nonapoptotic RCD by delivery of cargoes to regulate tumor progression. Additionally, the review delves into the potential clinical applications of EV-mediated cell death and its significance in the areas of cancer diagnosis and therapy.

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