Cellular Models in Autoinflammatory Disease Research

Overview

Journal Clin Transl Immunology

Specialty Allergy & Immunology

Date 2024 Jan 12

PMID 38213819

Authors

Basak Sen

Banu Balci-Peynircioglu

Affiliations

Soon will be listed here.

Abstract

Systemic autoinflammatory diseases are a heterogeneous group of rare genetic disorders caused by dysregulation of the innate immune system. Understanding the complex mechanisms underlying these conditions is critical for developing effective treatments. Cellular models are essential for identifying new conditions and studying their pathogenesis. Traditionally, these studies have used primary cells and cell lines of disease-relevant cell types, although newer induced pluripotent stem cell (iPSC)-based models might have unique advantages. In this review, we discuss the three cellular models used in autoinflammatory disease research, their strengths and weaknesses, and their applications to inform future research in the field.

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