Stay in Touch with the Endoplasmic Reticulum

Overview

Journal Sci China Life Sci

Specialties Biology
Science

Date 2024 Jan 11

PMID 38212460

Authors

Sha Sun

Gan Zhao

Mingkang Jia

Qing Jiang

Shulin Li

Haibin Wang

Wenjing Li

Yunyun Wang

Xin Bian

Yan G Zhao

Xun Huang

Ge Yang

Huaqing Cai

Jose C Pastor-Pareja

Liang Ge

Chuanmao Zhang

Junjie Hu

Affiliations

Soon will be listed here.

Abstract

The endoplasmic reticulum (ER), which is composed of a continuous network of tubules and sheets, forms the most widely distributed membrane system in eukaryotic cells. As a result, it engages a variety of organelles by establishing membrane contact sites (MCSs). These contacts regulate organelle positioning and remodeling, including fusion and fission, facilitate precise lipid exchange, and couple vital signaling events. Here, we systematically review recent advances and converging themes on ER-involved organellar contact. The molecular basis, cellular influence, and potential physiological functions for ER/nuclear envelope contacts with mitochondria, Golgi, endosomes, lysosomes, lipid droplets, autophagosomes, and plasma membrane are summarized.

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