Body Temperature in the Acute Phase and Clinical Outcomes After Acute Ischemic Stroke

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2024 Jan 11

PMID 38206979

Authors

Satomi Mezuki

Ryu Matsuo

Fumi Irie

Yuji Shono

Takahiro Kuwashiro

Hiroshi Sugimori

Yoshinobu Wakisaka

Tetsuro Ago

Masahiro Kamouchi

Takanari Kitazono

Affiliations

Soon will be listed here.

Abstract

Background: This study aimed to examine whether post-stroke early body temperature is associated with neurological damage in the acute phase and functional outcomes at three months.

Methods: We included 7,177 patients with acute ischemic stroke within 24 h of onset. Axillary temperature was measured daily in the morning for seven days. Mean body temperature was grouped into five quintiles (Q1: 35.1‒36.5°C, Q2: 36.5‒36.7°C, Q3: 36.7‒36.8°C, Q4: 36.8‒37.1°C, and Q5: 37.1‒39.1°C). Clinical outcomes included neurological improvement during hospitalization and poor functional outcome (modified Rankin scale score, 3-6) at three months. A logistic regression analysis was performed to evaluate the association between body temperature and clinical outcomes.

Results: The patient's mean (SD) age was 70.6 (12.3) years, and 35.7% of patients were women. Mean body temperature was significantly associated with less neurological improvement from Q2 (odds ratios [95% confidence interval], 0.77 [0.65-0.99] vs. Q1) to Q5 (0.33 [0.28-0.40], P for trend <0.001) even after adjusting for potential confounders, including baseline neurological severity, C-reactive protein levels, and post-stroke acute infections. The multivariable-adjusted risk of poor functional outcome linearly increased from Q2 (1.36 [1.03-1.79]) to Q5 (6.44 [5.19-8.96], P for trend <0.001). These associations were maintained even in the analyses excluding patients with acute infectious diseases. Multivariable-adjusted risk of poor functional outcome was higher in patients with early body temperature elevation on days 1-3 and with longer duration with body temperature >37.0°C.

Conclusions: Post-stroke early high body temperature is independently associated with unfavorable outcomes following acute ischemic stroke.

Citing Articles

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