Germline Gene Fusions Across Species Reveal the Chromosomal Instability Regions and Cancer Susceptibility

Overview

Journal iScience

Publisher Cell Press

Date 2024 Jan 11

PMID 38205119

Authors

Bo-Wen Zhou

Qing-Qin Wu

David H Mauki

Xuan Wang

Shu-Run Zhang

Ting-Ting Yin

Fang-Liang Chen

Chao Li

Yan-Hu Liu

Guo-Dong Wang

Ya-Ping Zhang

Affiliations

Soon will be listed here.

Abstract

The canine transmissible venereal tumor (CTVT) is a clonal cell-mediated cancer with a long evolutionary history and extensive karyotype rearrangements in its genome. However, little is known about its genetic similarity to human tumors. Here, using multi-omics data we identified 11 germline gene fusions (GGFs) in CTVT, which showed higher genetic susceptibility than others. Additionally, we illustrate a mechanism of a complex gene fusion of three gene segments (--) that we refer to "greedy fusion". Our findings also provided evidence that expressions of GGFs are downregulated during the tumor regressive phase, which is associated with DNA methylation level. This study presents a comprehensive landscape of gene fusions (GFs) in CTVT, which offers a valuable genetic resource for exploring potential genetic mechanisms underlying the development of cancers in both dogs and humans.

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