Evaluating Proxies for Motion Sickness in Rodent

Overview

Journal IBRO Neurosci Rep

Specialty Neurology

Date 2024 Jan 11

PMID 38204574

Authors

Fu-Xing Zhang

Xiao-Hang Xie

Zi-Xin Guo

Hao-Dong Wang

Hui Li

Kenneth Lap Kei Wu

Ying-Shing Chan

Yun-Qing Li

Affiliations

Soon will be listed here.

Abstract

Motions sickness (MS) occurs when the brain receives conflicting sensory signals from vestibular, visual and proprioceptive systems about a person's ongoing position and/or motion in relation to space. MS is typified by symptoms such as nausea and emesis and implicates complex physiological aspects of sensations and sensorimotor reflexes. Use of animal models has been integral to unraveling the physiological causality of MS. The commonly used rodents (rat and mouse), albeit lacking vomiting reflex, reliably display phenotypic behaviors of pica (eating of non-nutritive substance) and conditioned taste aversion (CTAver) or avoidance (CTAvoi) which utilize neural substrates with pathways that cause gastrointestinal malaise akin to nausea/emesis. As such, rodent pica and CTAver/CTAvoi have been widely used as proxies for nausea/emesis in studies dealing with neural mechanisms of nausea/emesis and MS, as well as for evaluating therapeutics. This review presents the rationale and experimental evidence that support the use of pica and CTAver/CTAvoi as indices for nausea and emesis. Key experimental steps and cautions required when using rodent MS models are also discussed. Finally, future directions are suggested for studying MS with rodent pica and CTAver/CTAvoi models.

References

Javid F, Naylor R . Variables of movement amplitude and frequency in the development of motion sickness in Suncus murinus. Pharmacol Biochem Behav. 1999; 64(1):115-22. DOI: 10.1016/s0091-3057(99)00066-0. View

Gallo M, Marquez S, Ballesteros M, Maldonado A . Functional blockade of the parabrachial area by tetrodotoxin disrupts the acquisition of conditioned taste aversion induced by motion-sickness in rats. Neurosci Lett. 1999; 265(1):57-60. DOI: 10.1016/s0304-3940(99)00209-8. View

Bertolini G, Straumann D . Moving in a Moving World: A Review on Vestibular Motion Sickness. Front Neurol. 2016; 7:14. PMC: 4753518. DOI: 10.3389/fneur.2016.00014. View

Rudd J, Ngan M, Wai M . 5-HT3 receptors are not involved in conditioned taste aversions induced by 5-hydroxytryptamine, ipecacuanha or cisplatin. Eur J Pharmacol. 1998; 352(2-3):143-9. DOI: 10.1016/s0014-2999(98)00359-8. View

Yates B, Catanzaro M, Miller D, McCall A . Integration of vestibular and emetic gastrointestinal signals that produce nausea and vomiting: potential contributions to motion sickness. Exp Brain Res. 2014; 232(8):2455-69. PMC: 4112154. DOI: 10.1007/s00221-014-3937-6. View

Lackner J . Motion sickness: more than nausea and vomiting. Exp Brain Res. 2014; 232(8):2493-510. PMC: 4112051. DOI: 10.1007/s00221-014-4008-8. View

Sato G, Uno A, Horii A, Umehara H, Kitamura Y, Sekine K . Effects of hypergravity on histamine H1 receptor mRNA expression in hypothalamus and brainstem of rats: implications for development of motion sickness. Acta Otolaryngol. 2008; 129(1):45-51. DOI: 10.1080/00016480802008173. View

Rudd J, Chan S, Ngan M, Tu L, Lu Z, Giuliano C . Anti-emetic Action of the Brain-Penetrating New Ghrelin Agonist, HM01, Alone and in Combination With the 5-HT Antagonist, Palonosetron and With the NK Antagonist, Netupitant, Against Cisplatin- and Motion-Induced Emesis in (House Musk Shrew). Front Pharmacol. 2018; 9:869. PMC: 6087754. DOI: 10.3389/fphar.2018.00869. View

Horowitz S, Blanchard J, Morin L . Medial vestibular connections with the hypocretin (orexin) system. J Comp Neurol. 2005; 487(2):127-46. DOI: 10.1002/cne.20521. View

10.

Sanger G, Holbrook J, Andrews P . The translational value of rodent gastrointestinal functions: a cautionary tale. Trends Pharmacol Sci. 2011; 32(7):402-9. DOI: 10.1016/j.tips.2011.03.009. View

11.

Singh P, Kuo B . Central Aspects of Nausea and Vomiting in GI Disorders. Curr Treat Options Gastroenterol. 2016; 14(4):444-451. DOI: 10.1007/s11938-016-0107-x. View

12.

Rudd J, Ngan M, Wai M . Inhibition of emesis by tachykinin NK1 receptor antagonists in Suncus murinus (house musk shrew). Eur J Pharmacol. 1999; 366(2-3):243-52. DOI: 10.1016/s0014-2999(98)00920-0. View

13.

Idoux E, Tagliabue M, Beraneck M . No Gain No Pain: Relations Between Vestibulo-Ocular Reflexes and Motion Sickness in Mice. Front Neurol. 2018; 9:918. PMC: 6240678. DOI: 10.3389/fneur.2018.00918. View

14.

Aung H, Mehendale S, Chang W, Wang C, Xie J, Yuan C . Scutellaria baicalensis decreases ritonavir-induced nausea. AIDS Res Ther. 2005; 2:12. PMC: 1352373. DOI: 10.1186/1742-6405-2-12. View

15.

Dieterich M, Brandt T . The bilateral central vestibular system: its pathways, functions, and disorders. Ann N Y Acad Sci. 2015; 1343:10-26. DOI: 10.1111/nyas.12585. View

16.

Leung A, Hon K . Motion sickness: an overview. Drugs Context. 2020; 8. PMC: 7048153. DOI: 10.7573/dic.2019-9-4. View

17.

Reilly S, Bornovalova M . Conditioned taste aversion and amygdala lesions in the rat: a critical review. Neurosci Biobehav Rev. 2005; 29(7):1067-88. DOI: 10.1016/j.neubiorev.2005.03.025. View

18.

Yu X, Cai G, Liu A, Chu Z, Su D . A novel animal model for motion sickness and its first application in rodents. Physiol Behav. 2007; 92(4):702-7. DOI: 10.1016/j.physbeh.2007.05.067. View

19.

Rinaman L, Saboury M, Litvina E . Ondansetron blocks LiCl-induced conditioned place avoidance but not conditioned taste/flavor avoidance in rats. Physiol Behav. 2009; 98(4):381-5. PMC: 2756646. DOI: 10.1016/j.physbeh.2009.06.017. View

20.

Zhang Z, Liu L, Fang Y, Wang X, Wang W, Chan Y . A New Vestibular Stimulation Mode for Motion Sickness With Emphatic Analysis of Pica. Front Behav Neurosci. 2022; 16:882695. PMC: 9115577. DOI: 10.3389/fnbeh.2022.882695. View