The Promoting Role of HK II in Tumor Development and the Research Progress of Its Inhibitors

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2024 Jan 11

PMID 38202657

Authors

Bingru Liu

Yu Lu

Ayijiang Taledaohan

Shi Qiao

Qingyan Li

Yuji Wang

Affiliations

Soon will be listed here.

Abstract

Increased glycolysis is a key characteristic of malignant cells that contributes to their high proliferation rates and ability to develop drug resistance. The glycolysis rate-limiting enzyme hexokinase II (HK II) is overexpressed in most tumor cells and significantly affects tumor development. This paper examines the structure of HK II and the specific biological factors that influence its role in tumor development, as well as the potential of HK II inhibitors in antitumor therapy. Furthermore, we identify and discuss the inhibitors of HK II that have been reported in the literature.

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