Phytochemical Profile, GC-MS Profiling and In Vitro Evaluation of Some Biological Applications of the Extracts of L. and D.C

Overview

Journal Plants (Basel)

Date 2024 Jan 11

PMID 38202445

Authors

Michella Dawra

Jalloul Bouajila

Marc El Beyrouthy

Patricia Taillandier

Nancy Nehme

Youssef El Rayess

Affiliations

Soon will be listed here.

Abstract

Indigenous to Lebanon, L. and D.C. are notable plants in the Middle East, with known for its aromatic qualities and being less explored. Both plants have a significant role in traditional medicine for treating various ailments. This study aimed to evaluate the phytochemical composition and biological properties of the extracts from these plants. The extracts were obtained through cold maceration with solvents of increasing polarity. The ethyl acetate extract of exhibited the highest total polyphenol content. High-performance liquid chromatography (HPLC) identified fifteen compounds in both and extracts, whereas gas chromatography-mass spectrometry (GC-MS) analysis unveiled 179 volatile compounds. Notably, the -MeOH extract showed moderate antioxidant activity. Both plants' methanolic extracts demonstrated significant anti-Alzheimer's potential. The -dichloromethane and -cyclohexane extracts displayed the highest cytotoxicities against the HCT-116 cell line. For anti-proliferative activity against the Caco-2 cell line, the -methanol and -cyclohexane extracts were the most effective. This study provides valuable insights into the phytochemistry and potential therapeutic applications of extracts from these two oriental plant species.

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