Sonographic, Demographic, and Clinical Characteristics of Pre- and Postmenopausal Women with Endometrial Cancer; Results from a Post Hoc Analysis of the IETA4 (International Endometrial Tumor Analysis) Multicenter Cohort

Overview

Journal Diagnostics (Basel)

Specialty Radiology

Date 2024 Jan 11

PMID 38201310

Authors

Rasmus W Green

Daniela Fischerova

Antonia C Testa

Dorella Franchi

Filip Fruhauf

Pelle G Lindqvist

Alessia di Legge

David Cibula

Robert Fruscio

Lucia A Haak

Gina Opolskiene

Ailyn M Vidal Urbinati

Dirk Timmerman

Tom Bourne

Thierry Van den Bosch

Elisabeth Epstein

Affiliations

Soon will be listed here.

Abstract

In this study, we conducted a comparative analysis of demographic, histopathological, and sonographic characteristics between pre- and postmenopausal women diagnosed with endometrial cancer, while also examining sonographic and anthropometric features in 'low' and 'intermediate/high-risk' cases, stratified by menopausal status. Our analysis, based on data from the International Endometrial Tumor Analysis (IETA) 4 cohort comprising 1538 women (161 premenopausal, 1377 postmenopausal) with biopsy-confirmed endometrial cancer, revealed that premenopausal women, compared to their postmenopausal counterparts, exhibited lower parity (median 1, IQR 0-2 vs. 1, IQR 1-2, = 0.001), a higher family history of colon cancer (16% vs. 7%, = 0.001), and smaller waist circumferences (median 92 cm, IQR 82-108 cm vs. 98 cm, IQR 87-112 cm, = 0.002). Premenopausal women more often had a regular endometrial-myometrial border (39% vs. 23%, < 0.001), a visible endometrial midline (23% vs. 11%, < 0.001), and undefined tumor (73% vs. 84%, 0.001). Notably, despite experiencing a longer duration of abnormal uterine bleeding (median 5 months, IQR 3-12 vs. 3 months, 2-6, < 0.001), premenopausal women more often had 'low' risk disease (78% vs. 46%, < 0.001). Among sonographic and anthropometric features, only an irregular endometrial-myometrial border was associated with 'intermediate/high' risk in premenopausal women. Conversely, in postmenopausal women, multiple features correlated with 'intermediate/high' risk disease. Our findings emphasize the importance of considering menopausal status when evaluating sonographic features in women with endometrial cancer.

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