Regulation of MA Methylome in Cancer: Mechanisms, Implications, and Therapeutic Strategies

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2024 Jan 11

PMID 38201270

Authors

Poshan Yugal Bhattarai

Garam Kim

Dibikshya Bhandari

Pratikshya Shrestha

Hong Seok Choi

Affiliations

Soon will be listed here.

Abstract

Reversible -adenosine methylation of mRNA, referred to as mA modification, has emerged as an important regulator of post-transcriptional RNA processing. Numerous studies have highlighted its crucial role in the pathogenesis of diverse diseases, particularly cancer. Post-translational modifications of mA-related proteins play a fundamental role in regulating the mA methylome, thereby influencing the fate of mA-methylated RNA. A comprehensive understanding of the mechanisms that regulate mA-related proteins and the factors contributing to the specificity of mA deposition has the potential to unveil novel therapeutic strategies for cancer treatment. This review provides an in-depth overview of our current knowledge of post-translational modifications of mA-related proteins, associated signaling pathways, and the mechanisms that drive the specificity of mA modifications. Additionally, we explored the role of mA-dependent mechanisms in the progression of various human cancers. Together, this review summarizes the mechanisms underlying the regulation of the mA methylome to provide insight into its potential as a novel therapeutic strategy for the treatment of cancer.

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