Effects of a 12-week Exercise-based Intervention on Weight Management in Overweight or Obese Breast Cancer Survivors: a Randomized Controlled Trial

Overview

Journal Support Care Cancer

Specialties Critical Care
Oncology

Date 2024 Jan 10

PMID 38200265

Authors

Fu-Yun Zhao

Jun-E Liu

Xiao-Ming Fang

Lu Chen

Jia-Gui Liang

Yu Liu

Ruo-Lin Li

Hai-Rong Chen

Affiliations

Soon will be listed here.

Abstract

Purpose: Breast cancer survivors face dual challenges: long-term sequelae of treatment and the risk of recurrent disease. Furthermore, obesity and a sedentary lifestyle can complicate both challenges. We aimed to assess the effect of a 12-week exercise-based weight-management program in overweight/obese breast cancer survivors.

Methods: A two-arm, single-blinded, randomized controlled trial was conducted among 60 overweight/obese, stage 0-III breast cancer survivors. During the 12-week program, the intervention group received weekly information support, fortnightly exercise prescriptions, including aerobic and resistance exercises to perform at home, and one dietary instruction. The control group received information support about weight management and exercise. Weight, body composition, and physical fitness data were collected at baseline, postintervention, and the 3-month follow-up.

Results: The intervention group showed significant improvements in body weight and all adiposity indices, including body mass index, waist circumference, and %body fat, in comparison with baseline (P < 0.001) and the control group (P < 0.05). Both groups showed no significant changes in fat-free mass during the 6-month period (P > 0.05). International Physical Activity Questionnaire scores and left grip strength increased significantly in the intervention group in comparison with the baseline (P < 0.01) and the control group (P < 0.05). Right grip strength, lower-body strength, and aerobic endurance showed no significant intergroup differences (P > 0.05).

Conclusions: A combination of exercise prescription and weight-loss interventions yielded clinically meaningful weight loss in overweight/obese breast cancer survivors. These findings may facilitate the incorporation of home-based exercise and weight management into breast cancer treatment and survivorship care.

Citing Articles

The effects of exercise interventions on fatigue, body composition, physical fitness, and biomarkers in breast cancer patients during and after treatment: a systematic review and meta-analysis of randomized controlled trials.

Lee J, Hwang Y J Cancer Surviv. 2025; .

PMID: 40056311 DOI: 10.1007/s11764-025-01772-x.

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