Sex-specific Differences in Patients with Psoriatic Arthritis:a Nationwide Study from the Chinese Registry of Psoriatic Arthritis (CREPAR IV)

Overview

Journal Clin Rheumatol

Publisher Springer

Specialty Rheumatology

Date 2024 Jan 10

PMID 38200254

Authors

Shihao He

Fan Yang

Chaofan Lu

Yanhong Wang

Xinwang Duan

Hongbin Li

Lijun Wu

Yongfu Wang

Jinmei Su

Mengtao Li

Xiaomei Leng

Xiaofeng Zeng

Affiliations

Soon will be listed here.

Abstract

Objectives: To elucidate the sex-specific differences in demographic features, clinical characteristics, and quality of life in Chinese patients with psoriatic arthritis (PsA).

Methods: A total of 1,074 patients with PsA registered between December 2018 and June 2021 from the Chinese REgistry of Psoriatic ARthritis (CREPAR) cohort were selected. The baseline data on demographics, clinical characteristics, commonly used laboratory tests, comorbidities, and quality of life assessments were collected for this cross-sectional analysis.

Results: A total of 1,074 patients were included in this study, 585 (54.47%) of them were male and 489 (45.53%) were female. The age at PsA onset in male patients was earlier than that in female patients (38.10 ± 12.79 vs 40.37 ± 13.41, p = 0.005). For clinical characteristics, male patients presented with higher rates of axial involvement (43.89% vs 37.74%, p = 0.044) and nail involvement (66.15% vs 58.08%, p = 0.006), while female patients presented with higher rates of peripheral arthritis (89.57% vs 83.93%, p = 0.007). For laboratory tests, men presented with a higher percentage of HLA-B27 positivity than women (24.65% vs 16.70%, p = 0.002) and had higher levels of CRP (median 9.70 vs 5.65, p < 0.001). Regarding disease assessment indices, male patients scored higher in PASI and BASFI (median 5.00 vs 3.00, p = 0.007 and 1.80 vs 1.40, p = 0.012, respectively). No sex difference was found in rates of achieving remission. Factors associated with disease remission were also analyzed in both sexes.

Conclusion: Demographic and clinical characteristics tend to vary between male and female patients with PsA. Male patients reported more functional limitations in daily life. Key Points • The demographic and clinical features vary greatly between male and female patients with PsA. • Male patients reported more functional burden in daily life as measured by BASFI.

Citing Articles

Psoriasis and Seasonality: Exploring the Genetic and Epigenetic Interactions.

Niedzwiedz M, Skibinska M, Ciazynska M, Noweta M, Czerwinska A, Krzyscin J Int J Mol Sci. 2024; 25(21).

PMID: 39519223 PMC: 11547062. DOI: 10.3390/ijms252111670.

Clinical Features and Disease Activity in Psoriatic Arthritis: A Sex-Related Perspective on Leptin and Comorbidity.

Toledano E, Gomez-Lechon L, Chacon C, Hidalgo C, Ibanez M, Marquez A J Clin Med. 2024; 13(10).

PMID: 38792501 PMC: 11121807. DOI: 10.3390/jcm13102959.

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